Evidence map›Paper›PMID 36146940›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity.

Amr Sonousi, Rasha A Hassan, Eman O Osman, Amr M Abdou, Soha H Emam

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. RSC advances · 2024
    Article
  9. Design, synthesis,Heliyon · 2024
    Article
  10. Novel pyrazolo[3,4-RSC medicinal chemistry · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amr SonousiPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Rasha A HassanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Eman O OsmanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Amr M AbdouDepartment of Microbiology and Immunology, National Research Centre, Dokki, Giza, Egypt.
Soha H EmamPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nineteen new quinazolin-4(3

Indexed as

Antineoplastic AgentsCytostatic AgentsApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorErbB ReceptorsErlotinib HydrochlorideHumansMolecular StructureProtein Kinase InhibitorsQuinazolinonesStructure-Activity RelationshipAntineoplastic AgentsCytostatic AgentsEGFR protein, humanErbB ReceptorsErlotinib HydrochlorideProtein Kinase InhibitorsQuinazolinonesantiproliferative activitycell cycle analysisEGFR inhibitionmolecular modellingQuinazolin-4(3H)-one

Identifiers

PMID36146940
PMCPMC9518264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.