Evidence map›Paper›PMID 36146932›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2023

NAMPT is a metabolic checkpoint of IFNγ-producing CD4

Mengyuan Li, Yimei Lai, Binfeng Chen, Chaohuan Guo, Mianjing Zhou, Siyuan Zhao, Shuyi Wang, Jin Li, Niansheng Yang, Hui Zhang

Open access · greenAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Article
  3. Aging-related CD8PeerJ · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Weight Loss-Associated Remodeling of Adipose Tissue Immunometabolism.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  8. Review
  9. Immunometabolism in systemic lupus erythematosus.Nature reviews. Rheumatology · 2025
    Review
  10. TIGIT deficiency promotes autoreactive CD4Nature communications · 2025
    Article
  11. Article
  12. Article
  13. Aberrant METTL1-mediated tRNA mNature communications · 2024
    Article
  14. Article
  15. C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  16. Review
  17. Review
  18. NADCell & bioscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mengyuan LiDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Yimei LaiDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Binfeng ChenDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Chaohuan GuoDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Mianjing ZhouDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Siyuan ZhaoDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Shuyi WangDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Jin LiDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Niansheng YangDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Hui ZhangDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zhangh656@mail.sysu.edu.cn.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon γ (IFNγ) produced by T cells represents the featured cytokine and is central to the pathogenesis of lupus nephritis (LN). Here, we identified nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the salvage NAD

Indexed as

Interferon-gammaLupus NephritisAnimalsCD4-Positive T-LymphocytesCytokinesMiceMice, Inbred MRL lprNADNicotinamide PhosphoribosyltransferaseRNA, Small InterferingT-LymphocytesCytokinesInterferon-gammaNADNicotinamide PhosphoribosyltransferaseRNA, Small InterferingIFNγ expressionlupus nephritismetabolic checkpointNAMPTtranslation efficiency

Identifiers

PMID36146932
PMCPMC9840150
OpenAlexW4296803405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.