Evidence map›Paper›PMID 36146927›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII.

Tarfah Al-Warhi, Mostafa M Elbadawi, Alessandro Bonardi, Alessio Nocentini, Ahmed A Al-Karmalawy, Nada Aljaeed, Ohoud J Alotaibi, Hatem A Abdel-Aziz, Claudiu T Supuran, Wagdy M Eldehna

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 49 citations in OpenAlex.

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  14. Biological evaluation, docking studies, andJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Mostafa M ElbadawiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr el-sheikh, Egypt.ORCID 0000-0002-9073-4176
Alessandro BonardiDepartment of NE.UROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.
Alessio NocentiniDepartment of NE.UROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.ORCID 0000-0003-3342-702X
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, Egypt.ORCID 0000-0002-8173-6073
Nada AljaeedDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Ohoud J AlotaibiDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Hatem A Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center, Dokki, Egypt.
Claudiu T SupuranDepartment of NE.UROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.ORCID 0000-0003-4262-0323
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr el-sheikh, Egypt.
Princess Nourah bint Abdulrahman University · SAUniversity of Florence · ITKafrelsheikh University · EGEgyptian Russian University · EGNational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, different series of benzothiazole-based sulphonamides

Indexed as

Carbonic AnhydrasesNeoplasmsBenzothiazolesCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarboxylic AcidsEthylenesHumansPhenylurea CompoundsProtein IsoformsStructure-Activity RelationshipSulfonamidesZincBenzothiazolesCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesCarboxylic AcidsEthylenesPhenylurea CompoundsProtein IsoformsSLC-0111SulfonamidesZincanticancer agentshypoxic tumoursMetalloenzymessulphonamidesureido derivatives

Identifiers

PMID36146927
PMCPMC9518259
OpenAlexW4296801521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.