Evidence map›Paper›PMID 36146883›Full record

ArticleViruses2022

Quantification of APOBEC3 Mutation Rates Affecting the

Dorian McIlroy, Cécile Peltier, My-Linh Nguyen, Louise Manceau, Lenha Mobuchon, Nicolas Le Baut, Ngoc-Khanh Nguyen, Minh-Chau Tran, The-Cuong Nguyen, Céline Bressollette-Bodin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dorian McIlroyCenter for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, Nantes Université, CHU Nantes, INSERM, F-44000 Nantes, France.ORCID 0000-0002-3731-4017
Cécile PeltierCenter for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, Nantes Université, CHU Nantes, INSERM, F-44000 Nantes, France.ORCID 0000-0001-6535-2515
My-Linh NguyenDepartment of Medical Microbiology, Hanoi Medical University, Hanoi 116001, Vietnam.
Louise ManceauCenter for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, Nantes Université, CHU Nantes, INSERM, F-44000 Nantes, France.
Lenha MobuchonMolecular Biology and Sequencing Services, CHU Nantes, 44000 Nantes, France.ORCID 0000-0003-4938-2460
Nicolas Le BautCenter for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, Nantes Université, CHU Nantes, INSERM, F-44000 Nantes, France.
Ngoc-Khanh NguyenCenter for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, Nantes Université, CHU Nantes, INSERM, F-44000 Nantes, France.ORCID 0000-0002-8568-5875
Minh-Chau TranDepartment of Medical Microbiology, Hanoi Medical University, Hanoi 116001, Vietnam.
The-Cuong NguyenDepartment of Kidney Diseases and Dialysis, Vietduc University Hospital, Hanoi 110214, Vietnam.ORCID 0000-0003-1988-1656
Céline Bressollette-BodinCenter for Research in Transplantation and Translational Immunology, UMR 1064, ITUN, Nantes Université, CHU Nantes, INSERM, F-44000 Nantes, France.ORCID 0000-0001-5175-0790
Inserm · FRHanoi Medical University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the BK polyomavirus (BKPyV) capsid accumulate in kidney transplant (KTx) recipients with persistent virus replication. They are associated with neutralization escape and appear to arise as a result of cytosine deamination by host cell APOBEC3A/B enzymes. To study the mutagenic processes occurring in patients, we amplified the typing region of the

Indexed as

BK VirusPolyomavirus InfectionsAPOBEC DeaminasesCytidine DeaminaseCytosineHumansMutation RateProteinsAPOBEC3A protein, humanAPOBEC3 proteins, humanAPOBEC DeaminasesCytidine DeaminaseCytosineProteinsAPOBECinnate immunitypolyomavirusvirus evolution

Identifiers

PMID36146883
PMCPMC9504301
OpenAlexW4296810439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.