Evidence map›Paper›PMID 36146866›Full record

ArticleViruses2022

Foot-and-Mouth Disease Virus 3C

Pathum Ekanayaka, Asela Weerawardhana, Kiramage Chathuranga, Jong-Hyeon Park, Jong-Soo Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pathum EkanayakaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.ORCID 0000-0002-2388-3905
Asela WeerawardhanaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.ORCID 0000-0002-7412-5450
Kiramage ChathurangaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.ORCID 0000-0002-0279-2895
Jong-Hyeon ParkAnimal and Plant Quarantine Agency, Gimcheon-si 39660, Korea.ORCID 0000-0003-0825-8121
Jong-Soo LeeCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.ORCID 0000-0001-5119-0711
Chungnam National University · KRAnimal and Plant Quarantine Agency · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foot-and-mouth disease (FMD) is mainly characterized by blister formation (vesicles) in animals infected with foot-and-mouth disease virus (FMDV). However, the molecular basis of the blister formation in FMD is still unknown. BP180 is one of the main anchoring proteins connecting the dermal and epidermal layers of the skin. Previous studies have shown that the cleavage of BP180 by proteases produced by the inflammatory cells and the resulting skin loosening are major causes of the blister formation in bullous pemphigoid (BP) disease. Similar to BP, here we have demonstrated that, among the FMDV-encoded proteases, only FMDV 3C

Indexed as

Foot-and-Mouth DiseaseFoot-and-Mouth Disease VirusAnimalsBlisterCysteine EndopeptidasesPeptide HydrolasesViral ProteinsCysteine EndopeptidasesPeptide HydrolasesViral Proteinsblister formationBP180FMDV 3CproFMDV 3Cpro C142T substitutionskin loosening

Identifiers

PMID36146866
PMCPMC9503423
OpenAlexW4296753190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.