Evidence map›Paper›PMID 36146841›Full record

ArticleViruses2022

Expressing the Pro-Apoptotic Reaper Protein via Insertion into the Structural Open Reading Frame of Sindbis Virus Reduces the Ability to Infect

Alexis Carpenter, Scott R Santos, Rollie J Clem

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. bioRxiv : the preprint server for biology · 2023
    Article
  5. Factors Affecting Arbovirus Midgut Escape in Mosquitoes.Pathogens (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexis CarpenterDivision of Biology, Kansas State University, Manhattan, KS 66506, USA.
Scott R SantosDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Rollie J ClemDivision of Biology, Kansas State University, Manhattan, KS 66506, USA.ORCID 0000-0002-2368-720X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arboviruses continue to threaten a significant portion of the human population, and a better understanding is needed of the determinants of successful arbovirus infection of arthropod vectors. Avoiding apoptosis has been shown to be one such determinant. Previous work showed that a Sindbis virus (SINV) construct called MRE/rpr that expresses the

Indexed as

AedesSindbis VirusAnimalsApoptosis Regulatory ProteinsCaspases, EffectorHumansMosquito VectorsOpen Reading FramesApoptosis Regulatory ProteinsCaspases, Effectoralphavirusantiviral immunityapoptosisarbovirusmosquitoSindbis virusvector competence

Identifiers

PMID36146841
PMCPMC9501589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.