Evidence map›Paper›PMID 36146835›Full record

ArticleViruses2022

SARS-CoV-2 Monitoring in Wastewater Reveals Novel Variants and Biomarkers of Infection.

Jenna McGowan, Monica Borucki, Hicham Omairi, Merina Varghese, Shahnaz Vellani, Sukanya Chakravarty, Shumin Fan, Srestha Chattopadhyay, Mashuk Siddiquee, James B Thissen and 9 more

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jenna McGowanPhysiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Monica BoruckiPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.ORCID 0000-0003-2924-2313
Hicham OmairiDepartment of Civil and Environmental Engineering, University of Toledo College of Engineering, Toledo, OH 43607, USA.
Merina VargheseMedical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Shahnaz VellaniPhysiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0001-5750-9084
Sukanya ChakravartyMedical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Shumin FanMedical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Srestha ChattopadhyayCollege of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA.
Mashuk SiddiqueeDepartment of Civil and Environmental Engineering, University of Toledo College of Engineering, Toledo, OH 43607, USA.
James B ThissenPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Nisha MulakkenComputing Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Joseph MoonComputing Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Jeffrey KimbrelPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.ORCID 0000-0001-7213-9392
Amit K TiwariCollege of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA.ORCID 0000-0002-7427-7155
Roger Travis TaylorMedical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0002-3819-8548
Dae-Wook KangDepartment of Civil and Environmental Engineering, University of Toledo College of Engineering, Toledo, OH 43607, USA.ORCID 0000-0002-2585-1974
Crystal JaingPhysical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Ritu ChakravartiPhysiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0003-4680-8374
Saurabh ChattopadhyayMedical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0002-2930-1523

Funding

Anti-inflammatory functions for non-transcriptional IRF3R01AI155545 · NIAID · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI Saurabh Chattopadhyay · 2021 to 2026
$2.2M
Understanding the proviral role for TRAF6 interaction with the viral protease in flavivirus replication and pathogenesisR01AI153496 · NIAID · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI TAYLOR, ROGER TRAVIS · 2020 to 2024
$1.9M
Novel antiviral mechanisms of the interferon systemR01AI165521 · NIAID · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI Saurabh Chattopadhyay · 2022 to 2026
$1.7M
NIAID NIH HHS R01 AI153496NIAID NIH HHS R01 AI155545NIAID NIH HHS R01 AI165521NIH HHS AI153496NIH HHS AI155545NIH HHS AI165521
6 · The paper itself

Abstract

Wastewater-based epidemiology (WBE) is a popular tool for the early indication of community spread of infectious diseases. WBE emerged as an effective tool during the COVID-19 pandemic and has provided meaningful information to minimize the spread of infection. Here, we present a combination of analyses using the correlation of viral gene copies with clinical cases, sequencing of wastewater-derived RNA for the viral mutants, and correlative analyses of the viral gene copies with the bacterial biomarkers. Our study provides a unique platform for potentially using the WBE-derived results to predict the spread of COVID-19 and the emergence of new variants of concern. Further, we observed a strong correlation between the presence of SARS-CoV-2 and changes in the microbial community of wastewater, particularly the significant changes in bacterial genera belonging to the families of

Indexed as

COVID-19SARS-CoV-2BiomarkersHumansPandemicsRNARNA, ViralWastewaterBiomarkersRNARNA, ViralWastewaterbiomarkersCOVID-19SARS-CoV-2surveillancewastewater-based epidemiology

Identifiers

PMID36146835
PMCPMC9503862

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.