Evidence map›Paper›PMID 36146804›Full record

ArticleViruses2022

Infectious Bronchitis Virus: A Comprehensive Multilocus Genomic Analysis to Compare DMV/1639 and QX Strains.

Ana P da Silva, Rachel Jude, Rodrigo A Gallardo

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ana P da SilvaDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive, 4009 VM3B, Davis, CA 95616, USA.ORCID 0000-0002-2007-8484
Rachel JudeDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive, 4009 VM3B, Davis, CA 95616, USA.ORCID 0000-0002-5692-7265
Rodrigo A GallardoDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive, 4009 VM3B, Davis, CA 95616, USA.ORCID 0000-0003-4727-8256

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious bronchitis virus (IBV) is a highly variable RNA virus that affects chickens worldwide. Due to its inherited tendency to suffer point mutations and recombination events during viral replication, emergent IBV strains have been linked to nephropathogenic and reproductive disease that are more severe than typical respiratory disease, leading, in some cases, to mortality, severe production losses, and/or unsuccessful vaccination. QX and DMV/1639 strains are examples of the above-mentioned IBV evolutionary pathway and clinical outcome. In this study, our purpose was to systematically compare whole genomes of QX and DMV strains looking at each IBV gene individually. Phylogenetic analyses and amino acid site searches were performed in datasets obtained from GenBank accounting for all IBV genes and using our own relevant sequences as a basis. The QX dataset studied is more genetically diverse than the DMV dataset, partially due to the greater epidemiological diversity within the five QX strains used as a basis compared to the four DMV strains from our study. Historically, QX strains have emerged and spread earlier than DMV strains in Europe and Asia. Consequently, there are more QX sequences deposited in GenBank than DMV strains, assisting in the identification of a larger pool of QX strains. It is likely that a similar evolutionary pattern will be observed among DMV strains as they develop and spread in North America.

Indexed as

Coronavirus InfectionsInfectious bronchitis virusPoultry DiseasesAmino AcidsAnimalsChickensGenomicsPhylogenyAmino AcidsDMVinfectious bronchitisQXviral evolutionwhole genome sequencing

Identifiers

PMID36146804
PMCPMC9506221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.