Evidence map›Paper›PMID 36146798›Full record

ArticleViruses2022

Molecular Epidemiology and Trends in HIV-1 Transmitted Drug Resistance in Mozambique 1999-2018.

Nalia Ismael, Eduan Wilkinson, Isabel Mahumane, Hernane Gemusse, Jennifer Giandhari, Adilson Bauhofer, Adolfo Vubil, Pirolita Mambo, Lavanya Singh, Nédio Mabunda and 5 more

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nalia IsmaelInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Eduan WilkinsonCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7602, South Africa.ORCID 0000-0002-2503-9441
Isabel MahumaneInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Hernane GemusseInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Jennifer GiandhariKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0002-2944-4583
Adilson BauhoferInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.ORCID 0000-0001-8184-9695
Adolfo VubilInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Pirolita MamboInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Lavanya SinghKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0002-1726-4454
Nédio MabundaInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Dulce BilaElizabeth Glaser Pediatric AIDS Foundation in Mozambique, Avenida Agostinho Neto, Maputo 620, Mozambique.
Susan EngelbrechtDivision of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.ORCID 0000-0002-1318-5994
Eduardo GudoInstituto Nacional de Saúde (INS), Estrada Nacional N1, Marracuene 3943, Mozambique.
Richard LessellsKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0003-0926-710X
Túlio de OliveiraCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7602, South Africa.

Funding

Pitt-Mozambique Training Program (Pitt-MozHRTP) in SARS-CoV-2, Cardiovascular Disease, and Diabetes in People with HIVD43TW011827 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Lee H Harrison, JEAN BISIMWA NACHEGA · 2022 to 2026
$1.2M
FIC NIH HHS D43 TW011827
6 · The paper itself

Abstract

HIV drug resistance (HIVDR) can become a public health concern, especially in low- and middle-income countries where genotypic testing for people initiating antiretroviral therapy (ART) is not available. For first-line regimens to remain effective, levels of transmitted drug resistance (TDR) need to be monitored over time. To determine the temporal trends of TDR in Mozambique, a search for studies in PubMed and sequences in GenBank was performed. Only studies covering the

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsHIV SeropositivityDrug Resistance, ViralHumansMolecular EpidemiologyMozambiqueMutationPrevalenceReverse Transcriptase InhibitorsAnti-HIV AgentsReverse Transcriptase Inhibitorsdruggenetic diversityHIVmolecular epidemiologyMozambiquemutationsresistancetemporal trendtransmittedtreatment naïve

Identifiers

PMID36146798
PMCPMC9505726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.