Evidence map›Paper›PMID 36146728›Full record

ArticleViruses2022

Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking.

Renuk V Lakshmanan, Joshua A Hull, Luke Berry, Matthew Burg, Brian Bothner, Robert McKenna, Mavis Agbandje-McKenna

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Renuk V LakshmananDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Joshua A HullDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Luke BerryDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Matthew BurgDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Brian BothnerDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-1295-9609
Robert McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-2792-935X
Mavis Agbandje-McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
University of Florida · USMontana State University · US

Funding

Structural studies of AAV capsids and their glycan receptor interactionsR01GM082946 · NIGMS · UNIVERSITY OF FLORIDA · PI ROBERT MCKENNA · 2007 to 2026
$6.1M
The role of pH and protease activity in AAV viral transductionR01GM109524 · NIGMS · UNIVERSITY OF FLORIDA · PI AGBANDJE-MCKENNA, MAVIS, MCKENNA, ROBERT · 2014 to 2017
$2.0M
Structure and dynamics of the VP1u infectivity domain of the ParvoviridaeR21AI126583 · NIAID · UNIVERSITY OF FLORIDA · PI AGBANDJE-MCKENNA, MAVIS · 2016 to 2017
$420k
NIAID NIH HHS R21 AI126583NIGMS NIH HHS R01 GM082946NIGMS NIH HHS R01 GM109524NIH HHS AI126583
6 · The paper itself

Abstract

Parvovirus B19 (B19V) is a human pathogen that is the causative agent of fifth disease in children. It is also known to cause hydrops in fetuses, anemia in AIDS patients, and transient aplastic crisis in patients with sickle cell disease. The unique N-terminus of Viral Protein 1 (VP1u) of parvoviruses, including B19V, exhibits phospholipase A

Indexed as

Parvovirus B19, HumanVirus InternalizationCapsid ProteinsChildEndosomesHumansPhospholipases A2Viral ProteinsCapsid ProteinsPhospholipases A2Viral ProteinsB19VCD spectroscopyendosomal traffickingminute virus of miceMVMparvovirus B19phospholipasePLA2receptor binding domainstructurethermostabilityVP1u

Identifiers

PMID36146728
PMCPMC9505059
OpenAlexW4293723442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.