Evidence map›Paper›PMID 36146685›Full record

ArticleViruses2022

SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic.

Wael H Roshdy, Mohamed K Khalifa, James Emmanuel San, Houriiyah Tegally, Eduan Wilkinson, Shymaa Showky, Darren Patrick Martin, Monika Moir, Amel Naguib, Nancy Elguindy and 12 more

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Ligand-based design, synthesis, computational insights, andJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  7. Article
  8. Anticoagulants as Potential SARS-CoV-2 MInternational journal of molecular sciences · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Wael H RoshdyCentral Public Health Laboratory, Ministry of Health and Population, Cairo 11613, Egypt.ORCID 0000-0001-8412-3128
Mohamed K KhalifaOmicsense, Cairo 11799, Egypt.
James Emmanuel SanKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-5736-664X
Houriiyah TegallyKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-7102-8540
Eduan WilkinsonKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.ORCID 0000-0002-2503-9441
Shymaa ShowkyCentral Public Health Laboratory, Ministry of Health and Population, Cairo 11613, Egypt.
Darren Patrick MartinInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7700, South Africa.
Monika MoirCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.ORCID 0000-0003-1095-1910
Amel NaguibCentral Public Health Laboratory, Ministry of Health and Population, Cairo 11613, Egypt.
Nancy ElguindyCentral Public Health Laboratory, Ministry of Health and Population, Cairo 11613, Egypt.ORCID 0000-0002-5876-237X
Mokhtar R GomaaCentre of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0001-7947-3609
Manal FahimDepartment of Surveillance and Epidemiology, Ministry of Health and Population, Cairo 12622, Egypt.ORCID 0000-0002-7206-4818
Hanaa Abu ElsoodDepartment of Surveillance and Epidemiology, Ministry of Health and Population, Cairo 12622, Egypt.
Amira MohsenWorld Health Organization, Egypt Country Office, Cairo 12622, Egypt.
Ramy GalalPublic Health Initiative, Cairo 11613, Egypt.
Mohamed HassanyNational Hepatology and Tropical Medicine Research Institute, Ministry of Health and Population, Cairo 11613, Egypt.ORCID 0000-0002-6001-8793
Richard J LessellsKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt.ORCID 0000-0002-8173-6073
Rabeh El-SheshenyCentre of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0002-8798-2240
Ahmed M KandeilCentre of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0003-3253-6961
Mohamed A AliCentre of Scientific Excellence for Influenza Viruses, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0002-5615-3212
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.

Funding

World Health Organization 001
6 · The paper itself

Abstract

COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part of the national genomic surveillance, 1027 SARS-CoV-2 near whole-genomes were generated and published by the end of July 2021. Here we describe the genomic epidemiology of SARS-CoV-2 in Egypt over this period using a subset of 976 high-quality Egyptian genomes analyzed together with a representative set of global sequences within a phylogenetic framework. A single lineage, C.36, introduced early in the pandemic was responsible for most of the cases in Egypt. Furthermore, to remain dominant in the face of mounting immunity from previous infections and vaccinations, this lineage acquired several mutations known to confer an adaptive advantage. These results highlight the value of continuous genomic surveillance in regions where VOCs are not predominant and the need for enforcement of public health measures to prevent expansion of the existing lineages.

Indexed as

COVID-19SARS-CoV-2EgyptHumansMutationPandemicsPhylogenyEgyptgenomic epidemiologySARS-CoV-2

Identifiers

PMID36146685
PMCPMC9502207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.