Evidence map›Paper›PMID 36146669›Full record

ArticleViruses2022

Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.

Chen Li, Wen-Feng He, Long-Xi Li, Jing Chen, Guo-Qing Yang, Hong-Tao Chang, Hui-Min Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Evasion of the Antiviral Innate Immunity by PRV.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chen LiCollege of Life Science, Henan Agricultural University, Zhengzhou 450002, China.
Wen-Feng HeCollege of Life Science, Henan Agricultural University, Zhengzhou 450002, China.ORCID 0000-0002-8237-9215
Long-Xi LiCollege of Life Science, Henan Agricultural University, Zhengzhou 450002, China.
Jing ChenCollege of Life Science, Henan Agricultural University, Zhengzhou 450002, China.ORCID 0000-0002-2872-3353
Guo-Qing YangCollege of Life Science, Henan Agricultural University, Zhengzhou 450002, China.
Hong-Tao ChangCollege of Animal Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China.
Hui-Min LiuCollege of Life Science, Henan Agricultural University, Zhengzhou 450002, China.ORCID 0000-0002-2519-3799
Henan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type I interferon (IFN) plays an important role in the host defense against viral infection by inducing expression of interferon-stimulated genes (ISGs). In a previous study, we found that porcine interferon-stimulated gene 15 (ISG15) exhibited antiviral activity against PRV in vitro. To further investigate the antiviral function of ISG15 in vivo, we utilized ISG15 knockout (ISG15

Indexed as

Antiviral AgentsInterferon Type IAnimalsCytokinesFemaleInterferon-alphaMaleMiceMice, KnockoutSwineUbiquitinsAntiviral AgentsCytokinesInterferon-alphaInterferon Type IUbiquitinsimpairin vivoISG15 knockout micepseudorabies virussusceptibilitytype I IFN

Identifiers

PMID36146669
PMCPMC9502845
OpenAlexW4293224418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.