Evidence map›Paper›PMID 36146667›Full record

ArticleViruses2022

SARS-CoV-2 RBD-Specific Antibodies Induced Early in the Pandemic by Natural Infection and Vaccination Display Cross-Variant Binding and Inhibition.

Melanie R Walker, Daria Podlekareva, Stine Johnsen, Bonna Leerhøy, Cyrielle Fougeroux, Max Søgaard, Ali Salanti, Sisse Bolm Ditlev, Lea Barfod

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Melanie R WalkerCentre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-9731-9880
Daria PodlekarevaCentre for Translational Research, Bispebjerg Hospital, 2400 Copenhagen, Denmark.ORCID 0000-0003-3187-0597
Stine JohnsenCentre for Translational Research, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
Bonna LeerhøyCentre for Translational Research, Bispebjerg Hospital, 2400 Copenhagen, Denmark.ORCID 0000-0001-9025-5776
Cyrielle FougerouxCentre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Max SøgaardExpres2ion Biotechnologies, 2970 Hørsholm, Denmark.ORCID 0000-0001-6224-4818
Ali SalantiCentre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Sisse Bolm DitlevCentre for Translational Research, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
Lea BarfodCentre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Bispebjerg Hospital · DKUniversity of Copenhagen · DKExpreS2ion Biotechnologies (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of vaccine candidates for COVID-19 has been rapid, and those that are currently approved display high efficacy against the original circulating strains. However, recently, new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged with increased transmission rates and less susceptibility to vaccine induced immunity. A greater understanding of protection mechanisms, including antibody longevity and cross-reactivity towards the variants of concern (VoCs), is needed. In this study, samples collected in Denmark early in the pandemic from paucisymptomatic subjects (

Indexed as

COVID-19PandemicsAngiotensin-Converting Enzyme 2Antibodies, ViralBNT162 VaccineChAdOx1 nCoV-19HumansImmunoglobulin GSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationAngiotensin-Converting Enzyme 2Antibodies, ViralBNT162 VaccineChAdOx1 nCoV-19Immunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antibodyCOVID-19inhibitionSARS-CoV-2variants of concern

Identifiers

PMID36146667
PMCPMC9503696
OpenAlexW4293224567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.