Evidence map›Paper›PMID 36146637›Full record

ArticleVaccines2022

Intranasal Treatment of Ferrets with Inert Bacterial Spores Reduces Disease Caused by a Challenging H7N9 Avian Influenza Virus.

Joe James, Stephanie M Meyer, Huynh A Hong, Chau Dang, Ho T Y Linh, William Ferreira, Paidamoyo M Katsande, Linh Vo, Daniel Hynes, William Love and 2 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05984004 nacompletednot on this map

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety of Postbiotic Nasal Spray Using Killed Spores of Bacillus Subtilis DSM32444 in Healthy Volunteers

TypeinterventionalSponsorHuro Biotech Joint Stock CompanyRan2022 to 2023Enrolled60ConditionsRhino SinusitisArms0.9% NaCl isotonic saline solution, Bacillus subtilis DSM32444, inactivated
NCT05999955 nacompletednot on this map

An Open-label, Randomized, Active-controlled Study to Evaluate the Safety of Postbiotic Nasal Spray Using Inactivated DSM32444 Spores in the Treatment of Acute Rhinosinusitis, as Compared With Neomycin/ Dexamethasone/Xylometazoline Spray

TypeinterventionalSponsorHuro Biotech Joint Stock CompanyRan2022 to 2023Enrolled60ConditionsRhinosinusitis, RhinitisArmsNeomycin/ Dexameythasone/Xylometazoline, Bacillus subtilis DSM32444
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Joe JamesAnimal and Plant Health Agency (APHA), Woodham Lane, Weybridge KT15 3NB, Surrey, UK.ORCID 0000-0002-9673-3684
Stephanie M MeyerAnimal and Plant Health Agency (APHA), Woodham Lane, Weybridge KT15 3NB, Surrey, UK.
Huynh A HongSporeGen Ltd., London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK.
Chau DangSporeGen Ltd., London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK.
Ho T Y LinhHURO Biotech JSC, Lot A1-8, VL3 Road, Vinh Loc 2 Industrial Park, Long Hiep Commune, Ben Luc District, Long An, Vietnam.ORCID 0000-0001-9863-1879
William FerreiraSporeGen Ltd., London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK.ORCID 0000-0001-9163-556X
Paidamoyo M KatsandeDepartment of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, Surrey, UK.
Linh VoSporeGen Ltd., London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK.
Daniel HynesDestiny Pharma Plc., Sussex Innovation Centre, Science Park Square, Falmer, Brighton BN1 9SB, UK.
William LoveDestiny Pharma Plc., Sussex Innovation Centre, Science Park Square, Falmer, Brighton BN1 9SB, UK.
Ashley C BanyardAnimal and Plant Health Agency (APHA), Woodham Lane, Weybridge KT15 3NB, Surrey, UK.ORCID 0000-0002-1286-9825
Simon M CuttingSporeGen Ltd., London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK.
Animal and Plant Health Agency · GBRoyal Holloway University of London · GB

Funding

Innovate UK 72725
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacillus subtilisbacterial sporesinfluenzainnate immunityprophylaxis

Identifiers

PMID36146637
PMCPMC9502451
OpenAlexW4296753104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.