Evidence map›Paper›PMID 36146616›Full record

ReviewVaccines2022

SARS-CoV-2 Variants, Current Vaccines and Therapeutic Implications for COVID-19.

Hong-Yu Liang, Yuyan Wu, Vicky Yau, Huan-Xin Yin, Scott Lowe, Rachel Bentley, Mubashir Ayaz Ahmed, Wenjing Zhao, Chenyu Sun

Abstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Yu LiangThe Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, China.
Yuyan WuThe First People's Hospital of Hefei, 390 N. Huaihe Road, Luyang District, Hefei 230061, China.
Vicky YauDivision of Oral and Maxillofacial Surgery, Columbia University Irving Medical Center, 622W 168th St, New York, NY 10032, USA.ORCID 0000-0003-2981-6313
Huan-Xin YinThe Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, China.
Scott LoweCollege of Osteopathic Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO 64106, USA.
Rachel BentleyCollege of Osteopathic Medicine, Kansas City University, 1750 Independence Ave, Kansas City, MO 64106, USA.ORCID 0000-0003-4955-4269
Mubashir Ayaz AhmedAMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL 60657, USA.
Wenjing ZhaoNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Nantong Western Road, NO.98, Yangzhou 225000, China.
Chenyu SunNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Nantong Western Road, NO.98, Yangzhou 225000, China.ORCID 0000-0003-3812-3164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past two years, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused hundreds of millions of infections, resulting in an unprecedented pandemic of coronavirus disease 2019 (COVID-19). As the virus spreads through the population, ongoing mutations and adaptations are being discovered. There is now substantial clinical evidence that demonstrates the SARS-CoV-2 variants have stronger transmissibility and higher virulence compared to the wild-type strain of SARS-CoV-2. Hence, development of vaccines against SARS-CoV-2 variants to boost individual immunity has become essential. However, current treatment options are limited for COVID-19 caused by the SARS-CoV-2 variants. In this review, we describe current distribution, variation, biology, and clinical features of COVID-19 caused by SARS-CoV-2 variants (including Alpha (B.1.1.7 Lineage) variant, Beta (B.1.351 Lineage) variant, Gamma (P.1 Lineage) variant, Delta (B.1.617.2 Lineage) variant, and Omicron (B.1.1.529 Lineage) variant and others. In addition, we review currently employed vaccines in clinical or preclinical phases as well as potential targeted therapies in an attempt to provide better preventive and treatment strategies for COVID-19 caused by different SARS-CoV-2 variants.

Indexed as

COVID-19molecular therapeutic targetSARS-CoV-2 variantsvaccines

Identifiers

PMID36146616
PMCPMC9504858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.