Evidence map›Paper›PMID 36146576›Full record

ArticleVaccines2022

Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population.

Protim Sarker, Evana Akhtar, Rakib Ullah Kuddusi, Mohammed Mamun Alam, Md Ahsanul Haq, Md Biplob Hosen, Bikash Chandra Chanda, Farjana Haque, Muntasir Alam, Abdur Razzaque and 6 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Protim SarkerInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Evana AkhtarInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Rakib Ullah KuddusiInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0003-4577-1311
Mohammed Mamun AlamInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0003-0064-1812
Md Ahsanul HaqInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Md Biplob HosenInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0002-1701-7242
Bikash Chandra ChandaLaboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Farjana HaqueInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0001-8297-2652
Muntasir AlamInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Abdur RazzaqueHealth Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Mustafizur RahmanInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.
Faruque AhmedSheikh Russel Gastroliver Institute & Hospital, Dhaka 1212, Bangladesh.
Md Golam KibriaSheikh Russel Gastroliver Institute & Hospital, Dhaka 1212, Bangladesh.
Mohammed Zahirul IslamEmbassy of Sweden in Dhaka, Dhaka 1212, Bangladesh.
Shehlina AhmedForeign Commonwealth & Development Office (Bangladesh), Dhaka 1212, Bangladesh.
Rubhana RaqibInfectious Diseases Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0002-8116-4511
International Centre for Diarrhoeal Disease Research · BD

Funding

The Foreign, commonwealth & Development Office, FCDO GR-02142UNICEF GR-02141
6 · The paper itself

Abstract

backgroundThe adaptive immune response is a crucial component of the protective immunity against SARS-CoV-2, generated after infection or vaccination.

methodsWe studied antibody titers, neutralizing antibodies and cellular immune responses to four different COVID-19 vaccines, namely Pfizer-BioNTech, Moderna Spikevax, AstraZeneca and Sinopharm vaccines in the Bangladeshi population (

resultsmRNA vaccines Moderna (14,655 ± 11.3) and Pfizer (13,772 ± 11.5) elicited significantly higher anti-Spike (S) antibody titers compared to the Adenovector vaccine AstraZeneca (2443 ± 12.8) and inactivated vaccine Sinopharm (1150 ± 11.2). SARS-CoV-2-specific neutralizing antibodies as well as IFN-γ-secreting lymphocytes were more abundant in Pfizer and Moderna vaccine recipients compared to AstraZeneca and Sinopharm vaccine recipients. Participants previously infected with SARS-CoV-2 exhibited higher post-vaccine immune responses (S-specific and neutralizing antibodies, IFN-γ-secreting cells) compared to uninfected participants. Memory B (B

conclusionsmRNA vaccines generated a higher antibody response, while a differential cellular response was observed for different vaccine types, suggesting that both cellular and humoral responses are important in immune monitoring of different types of vaccines.

Indexed as

B cellcellular immunityhumoral immunityneutralizing antibodiesSARS-CoV-2T cell

Identifiers

PMID36146576
PMCPMC9504987
OpenAlexW4295094787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.