Evidence map›Paper›PMID 36146524›Full record

ReviewVaccines2022

Lessons Learned from the Development and Roll-Out of the rVSVΔG-ZEBOV-GP

Beth-Ann G Coller, William Lapps, Mahum Yunus, Samantha Bruno, Michael J Eichberg, Andrew Wen-Tseng Lee, Kenneth Liu, Rosybel Drury, Jules Millogo, Louis Robert Macareo and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. A Single-Dose Bundibugyo Virus Vaccine Protects Macaques Within 3 Days.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Beth-Ann G CollerMerck & Co., Inc., Rahway, NJ 07065, USA.ORCID 0000-0001-6006-1073
William LappsMerck & Co., Inc., Rahway, NJ 07065, USA.
Mahum YunusMerck & Co., Inc., Rahway, NJ 07065, USA.
Samantha BrunoMerck & Co., Inc., Rahway, NJ 07065, USA.
Michael J EichbergMerck & Co., Inc., Rahway, NJ 07065, USA.
Andrew Wen-Tseng LeeMerck & Co., Inc., Rahway, NJ 07065, USA.
Kenneth LiuMerck & Co., Inc., Rahway, NJ 07065, USA.
Rosybel DruryMSD, 69007 Lyon, France.
Jules MillogoMerck & Co., Inc., Rahway, NJ 07065, USA.
Louis Robert MacareoMerck & Co., Inc., Rahway, NJ 07065, USA.
Thomas H ArmstrongMerck & Co., Inc., Rahway, NJ 07065, USA.
Jeffrey T BlueMerck & Co., Inc., Rahway, NJ 07065, USA.
Lynne A IsopiMerck & Co., Inc., Rahway, NJ 07065, USA.
Melissa HughesMerck & Co., Inc., Rahway, NJ 07065, USA.
Susan M VanRheenenMerck & Co., Inc., Rahway, NJ 07065, USA.
Jonathan DeutschMerck & Co., Inc., Rahway, NJ 07065, USA.
Joan G TellMerck & Co., Inc., Rahway, NJ 07065, USA.ORCID 0000-0003-0558-1986
Sheri A DubeyMerck & Co., Inc., Rahway, NJ 07065, USA.
Merck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review describes key aspects of the development of the rVSVΔG-ZEBOV-GP Ebola vaccine and key activities which are continuing to further expand our knowledge of the product. Extensive partnerships and innovative approaches were used to address the various challenges encountered during this process. The rVSVΔG-ZEBOV-GP Ebola vaccine was initially approved by the European Medicines Agency and prequalified by the World Health Organization in November 2019. It was approved by the United States Food and Drug Administration in December 2019 and approved in five African countries within 90 days of prequalification. The development resulted in the first stockpile of a registered Ebola vaccine that is available to support outbreak response. This also provides insights into how the example of rVSVΔG-ZEBOV-GP can inform the development of vaccines for

Indexed as

ERVEBO®Marburg virusrecombinant vaccinerVSVSudan ebolavirusvesicular stomatitis virusZaire ebolavirus

Identifiers

PMID36146524
PMCPMC9505064
OpenAlexW4295094753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.