Evidence map›Paper›PMID 36146475›Full record

ArticleVaccines2022

Analysis of Adverse Effects of COVID-19 Vaccines in Spain following Booster Dose.

Esther Ríos, Sara Medrano, Mercedes Martínez, Consuelo Novella, Esther Marcos, Jose J Fernández, Alberto Delgado-Iribarren, Esther Culebras

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Esther RíosDepartment of Medicine, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain.ORCID 0000-0002-5604-5967
Sara MedranoDepartment of Clinical Microbiology, IdISSC, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Mercedes MartínezDepartment of Clinical Microbiology, IdISSC, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Consuelo NovellaDepartment of Clinical Microbiology, IdISSC, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Esther MarcosDepartment of Clinical Microbiology, IdISSC, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Jose J FernándezDepartamento de Biología del Servicio de Criminalística de la Guardia Civil, 28003 Madrid, Spain.
Alberto Delgado-IribarrenDepartment of Clinical Microbiology, IdISSC, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0001-7539-5404
Esther CulebrasDepartment of Clinical Microbiology, IdISSC, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Hospital Clínico San Carlos · ESGuardia Civil · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study evaluates the adverse effects of three vaccines: AstraZeneca (Vaxzevria), Pfizer/BioNTech (Comirnaty) and Moderna (Spikevax) according to the dose. From 733 participants collected, the vaccine schedule was as follows: 330 (45%) received a double dose of the AstraZeneca vaccine, 382 (52.1%) received a double dose of Pfizer, 18 (2.5%) received a heterologous prime boost and 3 (0.4%) received a single dose. Pfizer and Moderna vaccines were administered as a third dose in 70 and 121 individuals, respectively. Local and systemic reactions observed in the three vaccines were mild to moderate in severity. Only one AstraZeneca recipient (0.3%) presented a serious adverse effect: blurred vision. Adverse events were more frequent after the first dose of AstraZeneca and after the second dose of Pfizer. As the third dose, Moderna causes more adverse effects than Pfizer regardless of the type of vaccine previously administered, whereas the reactogenicity of a third dose of Pfizer is slightly higher in the group previously vaccinated with Pfizer than in that group with AstraZeneca. In short, secondary effects of the third dose of COVID-19 vaccines were similar to those after dose 2, but their frequency depends on the type of vaccine and the combinations of vaccines.

Indexed as

COVID-19 vaccinesheterologous prime–boostsecondary effectsserious eventthird dose

Identifiers

PMID36146475
PMCPMC9504129
OpenAlexW4293724773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.