Evidence map›Paper›PMID 36146457›Full record

ReviewVaccines2022

The

Calman Alexander MacLennan, Stephanie Grow, Lyou-Fu Ma, Andrew Duncan Steele

Registry-linked trialAbstract readReview
In one paragraph

Review in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06615375 (Phase 2b, Double-blind, Placebo-controlled Efficacy Challenge Study With the Shigella Tetravalent Bioconjugate Vaccine Shigella4V2), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06615375 phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation

Phase 2b, Double-blind, Placebo-controlled Efficacy Challenge Study With the Shigella Tetravalent Bioconjugate Vaccine Shigella4V2

TypeinterventionalSponsorLimmaTech Biologics AGRan2024 to 2026Enrolled120ConditionsShigellosisArmsShigella4V2, Placebo
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Threshold protective levels of serum IgG to Shigella lipopolysaccharide: re-analysis of Shigella vaccine trials data.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
    Trial
  5. Article
  6. Multifunctional antibody responses from a primateScience translational medicine · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Effects ofmedRxiv : the preprint server for health sciences · 2026
    Article
  12. Article
  13. The Burden and Genomic Characterization ofmedRxiv : the preprint server for health sciences · 2026
    Article
  14. Article
  15. OptimizingJournal of clinical microbiology · 2026
    Observational
  16. Development of a NovelVaccines · 2026
    Article
  17. Article
  18. Development of an 8-valentFrontiers in immunology · 2026
    Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Calman Alexander MacLennanEnteric & Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, 500 5th Ave. N, Seattle, WA 98109, USA.
Stephanie GrowEnteric & Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, 500 5th Ave. N, Seattle, WA 98109, USA.
Lyou-Fu MaEnteric & Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, 500 5th Ave. N, Seattle, WA 98109, USA.
Andrew Duncan SteeleEnteric & Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, 500 5th Ave. N, Seattle, WA 98109, USA.ORCID 0000-0002-4946-037X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

diarrheadysenteryflexneriglobal healthglycoconjugatelive attenuatedShigellashigellosissonneivaccines

Identifiers

PMID36146457
PMCPMC9504713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.