Evidence map›Paper›PMID 36146054›Full record

ArticlePolymers2022

Bioabsorbable Carboxymethyl Starch-Calcium Ionic Assembly Powder as a Hemostatic Agent.

Young-Gwang Ko, Byeong Nam Kim, Eun Jin Kim, Ho Yun Chung, Seong Yong Park, Young-Jin Kim, Oh Hyeong Kwon

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Clinical Evaluation of the Hemostatic Efficacy and Safety of a Biodegradable Hemostatic Agent, Hemogram: A Comparative Study with Arista™ AH.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Trial
  2. Review
  3. Article
  4. [Progress in application of medical absorbable haemostatic materials for haemostasis in orthopaedic surgery].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Young-Gwang KoDepartment of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea.
Byeong Nam KimTheracion Biomedical Co., Ltd., Seongnam 13201, Korea.
Eun Jin KimTheracion Biomedical Co., Ltd., Seongnam 13201, Korea.
Ho Yun ChungDepartment of Plastic and Reconstructive Surgery, CMRI, Kyungpook National University School of Medicine, Daegu 41944, Korea.ORCID 0000-0001-7359-3044
Seong Yong ParkDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
Young-Jin KimDepartment of Advanced Materials and Chemical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea.ORCID 0000-0002-1153-1304
Oh Hyeong KwonDepartment of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea.
Kumoh National Institute of Technology · KRDaegu Catholic University · KRKyungpook National University · KRSamsung Medical Center · KR

Funding

Ministry of Science ICT and Future Planning 2020R1I1A3072735Ministry of Science ICT and Future Planning IITP-2020-2020-0-01612
6 · The paper itself

Abstract

In contrast to hemostatic fabrics, foams, and gels, hemostatic spray powders may be conveniently applied on narrow and complex bleeding sites. However, powdered hemostatic agents are easily desorbed from the bleeding surface because of blood flow, which seriously decreases their hemostatic function. In this study, the hemostatic performance of a bioabsorbable powder with decreased desorption was investigated. The proposed hemostatic powder (OOZFIXTM) is an ionic assembly of carboxymethyl starch and calcium. The microstructure and chemical properties of the hemostatic powder were analyzed. The hemostatic performance (blood absorption, blood absorption rate, and coagulation time), thromboelastography (TEG), rheology, adhesion force, and C3a complement activation of the OOZFIXTM were evaluated and compared with those of the carboxymethyl starch-based commercial hemostatic powder (AristaTM AH). The in vivo rat hepatic hemorrhage model for hemostasis time and bioabsorption of the OOZFIXTM showed quick biodegradation (<3 weeks) and a significantly improved hemostasis rate (78 ± 17 s) compared to that of AristaTM AH (182 ± 11) because of the reduced desorption. The bioabsorbable hemostatic powder OOZFIXTM is expected to be a promising hemostatic agent for precise medical surgical treatments.

Indexed as

calciumcarboxymethyl starchhemostatic agentpowder

Identifiers

PMID36146054
PMCPMC9505345
OpenAlexW4296800699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.