Evidence map›Paper›PMID 36145962›Full record

ArticlePolymers2022

Breast Tissue Restoration after the Partial Mastectomy Using Polycaprolactone Scaffold.

Seung-Jun Jwa, Jong-Min Won, Do-Hyun Kim, Ki-Bum Kim, Jung-Bok Lee, Min Heo, Kyu-Sik Shim, Han-Saem Jo, Won-Jai Lee, Tai-Suk Roh and 1 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Advanced Hydrogels in Breast Cancer Therapy.Gels (Basel, Switzerland) · 2024
    Review
  4. Article
  5. Nedaplatin/Pharmaceutics · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. 3D Printing in Regenerative Medicine: Technologies and Resources Utilized.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Seung-Jun JwaDepartment of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0002-1552-1891
Jong-Min WonDepartment of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID 0000-0002-0827-7915
Do-Hyun KimPLCOskin Co., Ltd., Seoul 120-752, Korea.
Ki-Bum KimPLCOskin Co., Ltd., Seoul 120-752, Korea.
Jung-Bok LeeDepartment of Biological Science, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 04310, Korea.
Min HeoPLCOskin Co., Ltd., Seoul 120-752, Korea.
Kyu-Sik ShimDepartment of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Han-Saem JoDepartment of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Won-Jai LeeDepartment of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Tai-Suk RohDepartment of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Woo-Yeol BaekPLCOskin Co., Ltd., Seoul 120-752, Korea.ORCID 0000-0002-6638-4110
Yonsei University · KRSookmyung Women's University · KR

Funding

by a faculty research grant of Yonsei University College of Medicine 6-2019-0186the Ministry of Trade, Industry and Energy (MOTIE) and Korea Institute for Advancement of Technology Project No. P0019628
6 · The paper itself

Abstract

As breast conserving surgery increases in the surgical treatment of breast cancer, partial mastectomy is also increasing. Polycaprolactone (PCL) is a polymer that is used as an artifact in various parts of the human body based on the biocompatibility and mechanical properties of PCL. Here, we hypothesized that a PCL scaffold can be utilized for the restoration of breast tissue after a partial mastectomy. To demonstrate the hypothesis, a PCL scaffold was fabricated by 3D printing and three types of spherical PCL scaffold including PCL scaffold, PCL scaffold with collagen, and the PCL scaffold with breast tissue fragment were implanted in the rat breast defect model. After 6 months of implantation, the restoration of breast tissue was observed in the PCL scaffold and the expression of collagen in the PCL scaffold with collagen was seen. The expression of TNF-α was significantly increased in the PCL scaffold, but the expression of IL-6 showed no significant difference in all groups. Through this, it showed the possibility of using it as a method to conveniently repair tissue defects after partial mastectomy of the human body.

Indexed as

breast restorationpartial mastectomypolycaprolactonetissue restoration

Identifiers

PMID36145962
PMCPMC9501604
OpenAlexW4296588609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.