Evidence map›Paper›PMID 36145937›Full record

ArticlePolymers2022

Fabrication of Conductive Tissue Engineering Nanocomposite Films Based on Chitosan and Surfactant-Stabilized Graphene Dispersions.

Aleksandr S Buinov, Elvira R Gafarova, Ekaterina A Grebenik, Kseniia N Bardakova, Bato Ch Kholkhoev, Nadezhda N Veryasova, Pavel V Nikitin, Nastasia V Kosheleva, Boris S Shavkuta, Anastasia S Kuryanova and 2 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Aleksandr S BuinovBaikal Institute of Nature Management, Siberian Branch, Russian Academy of Sciences, Marii Sakh'yanovoi St. 6, 670047 Ulan-Ude, Russia.
Elvira R GafarovaInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.
Ekaterina A GrebenikInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.
Kseniia N BardakovaInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.ORCID 0000-0002-3942-5706
Bato Ch KholkhoevBaikal Institute of Nature Management, Siberian Branch, Russian Academy of Sciences, Marii Sakh'yanovoi St. 6, 670047 Ulan-Ude, Russia.
Nadezhda N VeryasovaInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.
Pavel V NikitinInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.
Nastasia V KoshelevaInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.
Boris S ShavkutaInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.
Anastasia S KuryanovaSemenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Kosygina St. 4, 119991 Moscow, Russia.
Vitalii F BurdukovskiiBaikal Institute of Nature Management, Siberian Branch, Russian Academy of Sciences, Marii Sakh'yanovoi St. 6, 670047 Ulan-Ude, Russia.
Peter S TimashevInstitute for Regenerative Medicine, Sechenov University, Trubetskaya St. 8-2, 119991 Moscow, Russia.ORCID 0000-0001-7773-2435
Sechenov University · RUBaikal Institute of Nature Management · RURussian Academy of Sciences · RUSemenov Institute of Chemical Physics · RU

Funding

Ministry of Science and Higher Education within the framework of State Assignment to the Baikal Institute of Nature Management, Siberian Branch of the Russian Academy of Sciences 0273-2021-0007Russian Foundation for Basic Research 20-33-90189Russian Science Foundation 18-15-00401
6 · The paper itself

Abstract

Chitosan (CS)/graphene nanocomposite films with tunable biomechanics, electroconductivity and biocompatibility using polyvinylpyrrolidone (PVP) and Pluronic F108 (Plu) as emulsion stabilizers for the purpose of conductive tissue engineering were successfully obtained. In order to obtain a composite solution, aqueous dispersions of multilayered graphene stabilized with Plu/PVP were supplied with CS at a ratio of CS to stabilizers of 2:1, respectively. Electroconductive films were obtained by the solution casting method. The electrical conductivity, mechanical properties and in vitro and in vivo biocompatibility of the resulting films were assessed in relation to the graphene concentration and stabilizer type and they were close to that of smooth muscle tissue. According to the results of the in vitro cytotoxicity analysis, the films did not release soluble cytotoxic components into the cell culture medium. The high adhesion of murine fibroblasts to the films indicated the absence of contact cytotoxicity. In subcutaneous implantation in Wistar rats, we found that stabilizers reduced the brittleness of the chitosan films and the inflammatory response.

Indexed as

biomaterialscellular adhesionchitosanelectrical conductivitygrapheneinflammatory reaction

Identifiers

PMID36145937
PMCPMC9503515
OpenAlexW4296588528

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.