Evidence map›Paper›PMID 36145899›Full record

ArticlePolymers2022

Matrix Regeneration Ability In Situ Induced by a Silk Fibroin Small-Caliber Artificial Blood Vessel In Vivo.

Helei Li, Mengnan Dai, Meng Li, Lingpeng Meng, Yangxiao Yu, Jianmei Xu, Fenglin Dong, Qingmin Fan, Yin Yin, Aiqing Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Helei LiCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Mengnan DaiCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Meng LiCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Lingpeng MengCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Yangxiao YuCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Jianmei XuCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Fenglin DongDepartment of Ultrasonography, First Affiliated Hospital, Soochow University, Suzhou 215006, China.
Qingmin FanDepartment of Ultrasonography, First Affiliated Hospital, Soochow University, Suzhou 215006, China.
Yin YinDepartment of Medicine, Soochow University, Suzhou 215123, China.
Aiqing WangDepartment of Medicine, Soochow University, Suzhou 215123, China.
Jiannan WangCollege of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.

Funding

National Natural Science Foundation of China 51873141, 51473108Natural Science Foundation of Jiangsu Province of China BK20181192
6 · The paper itself

Abstract

The success of a small-caliber artificial vascular graft in the host in order to obtain functional tissue regeneration and remodeling remains a great challenge in clinical application. In our previous work, a silk-based, small-caliber tubular scaffold (SFTS) showed excellent mechanical properties, long-term patency and rapid endothelialization capabilities. On this basis, the aim of the present study was to evaluate the vascular reconstruction process after implantation to replace the common carotid artery in rabbits. The new tissue on both sides of the SFTSs at 1 month was clearly observed. Inside the SFTSs, the extracellular matrix (ECM) was deposited on the pore wall at 1 month and continued to increase during the follow-up period. The self-assembled collagen fibers and elastic fibers were clearly visible in a circumferential arrangement at 6 months and were similar to autologous blood vessels. The positive expression rate of Lysyl oxidase-1 (LOXL-1) was positively correlated with the formation and maturity of collagen fibers and elastic fibers. In summary, the findings of the tissue regeneration processes indicated that the bionic SFTSs induced in situ angiogenesis in defects.

Indexed as

ECMmatrix fiber self-assemblysilk fibroinsmall-caliber artificial vessels

Identifiers

PMID36145899
PMCPMC9502482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.