Evidence map›Paper›PMID 36145892›Full record

ArticlePolymers2022

3D Printing of Triamcinolone Acetonide in Triblock Copolymers of Styrene-Isobutylene-Styrene as a Slow-Release System.

Philipp S Hilgeroth, Justus F Thümmler, Wolfgang H Binder

Abstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Philipp S HilgerothMacromolecular Chemistry, Institute of Chemistry, Martin-Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, 06120 Halle, Germany.
Justus F ThümmlerMacromolecular Chemistry, Institute of Chemistry, Martin-Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, 06120 Halle, Germany.
Wolfgang H BinderMacromolecular Chemistry, Institute of Chemistry, Martin-Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, 06120 Halle, Germany.ORCID 0000-0003-3834-5445

Funding

DFG Graduate School GRK 2670 project ID 43649874, TP B2, RTG 2670European Research Developmental Funds Graduate School AGRIPOLY
6 · The paper itself

Abstract

Additive manufacturing has a wide range of applications and has opened up new methods of drug formulation, in turn achieving attention in medicine. We prepared styrene-isobutylene-styrene triblock copolymers (SIBS; Mn = 10 kDa-25 kDa, PDI 1,3-1,6) as a drug carrier for triamcinolone acetonide (TA), further processed by fused deposition modeling to create a solid drug release system displaying improved bioavailability and applicability. Living carbocationic polymerization was used to exert control over block length and polymeric architecture. Thermorheological properties of the SIBS polymer (22.3 kDa, 38 wt % S) were adjusted to the printability of SIBS/TA mixtures (1-5% of TA), generating an effective release system effective for more than 60 days. Continuous drug release and morphological investigations were conducted to probe the influence of the 3D printing process on the drug release, enabling 3D printing as a formulation method for a slow-release system of Triamcinolone.

Indexed as

3D printingliving carbocationic polymerizationSIBS triblock copolymerTriamcinolone acetonide

Identifiers

PMID36145892
PMCPMC9504042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.