Evidence map›Paper›PMID 36145711›Full record

ReviewPharmaceutics2022

Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives.

Irene Paula Popa, Mihai Ștefan Cristian Haba, Minela Aida Mărănducă, Daniela Maria Tănase, Dragomir N Șerban, Lăcrămioara Ionela Șerban, Radu Iliescu, Ionuț Tudorancea

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026
    Trial
  3. Review
  4. Review
  5. Review
  6. Genetic polymorphisms inFrontiers in pharmacology · 2025
    Article
  7. Review
  8. Article
  9. Advances in the Insulin-Heart Axis: Current Therapies and Future Directions.International journal of molecular sciences · 2024
    Review
  10. The Role of Stem Cells in the Treatment of Cardiovascular Diseases.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Irene Paula PopaCardiology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iași, Romania.
Mihai Ștefan Cristian HabaCardiology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iași, Romania.
Minela Aida MărănducăDepartment of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID 0000-0002-2736-9700
Daniela Maria TănaseDepartment of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID 0000-0002-7144-2506
Dragomir N ȘerbanDepartment of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Lăcrămioara Ionela ȘerbanDepartment of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Radu IliescuDepartment of Pharmacology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Ionuț TudoranceaCardiology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iași, Romania.ORCID 0000-0002-4956-2595
Grigore T. Popa University of Medicine and Pharmacy · ROSpitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) is a progressively deteriorating medical condition that significantly reduces both the patients' life expectancy and quality of life. Even though real progress was made in the past decades in the discovery of novel pharmacological treatments for HF, the prevention of premature deaths has only been marginally alleviated. Despite the availability of a plethora of pharmaceutical approaches, proper management of HF is still challenging. Thus, a myriad of experimental and clinical studies focusing on the discovery of new and provocative underlying mechanisms of HF physiopathology pave the way for the development of novel HF therapeutic approaches. Furthermore, recent technological advances made possible the development of various interventional techniques and device-based approaches for the treatment of HF. Since many of these modern approaches interfere with various well-known pathological mechanisms in HF, they have a real ability to complement and or increase the efficiency of existing medications and thus improve the prognosis and survival rate of HF patients. Their promising and encouraging results reported to date compel the extension of heart failure treatment beyond the classical view. The aim of this review was to summarize modern approaches, new perspectives, and future directions for the treatment of HF.

Indexed as

angiotensin receptor–neprilysin inhibitorautonomic modulationcardiac myosin activationheart failuresodium-glucose co-transporter-2 inhibitorssoluble guanylate cyclase activator

Identifiers

PMID36145711
PMCPMC9503448
OpenAlexW4296268880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.