Evidence map›Paper›PMID 36145620›Full record

ArticlePharmaceutics2022

Combination of Poly(ε-Caprolactone) Biomaterials and Essential Oils to Achieve Anti-Bacterial and Osteo-Proliferative Properties for 3D-Scaffolds in Regenerative Medicine.

Sara Comini, Sara Scutera, Rosaria Sparti, Giuliana Banche, Bartolomeo Coppola, Cinzia Margherita Bertea, Gabriele Bianco, Noemi Gatti, Anna Maria Cuffini, Paola Palmero and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara CominiDepartment of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
Sara ScuteraDepartment of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.ORCID 0000-0002-7431-0875
Rosaria SpartiDepartment of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
Giuliana BancheDepartment of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.ORCID 0000-0003-2219-0223
Bartolomeo CoppolaDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Turin, Italy.ORCID 0000-0003-2167-2132
Cinzia Margherita BerteaDepartment of Life Sciences and Systems Biology, University of Torino, Via Quarello 15/A, 10135 Turin, Italy.ORCID 0000-0003-2919-0445
Gabriele BiancoMicrobiology and Virology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Corso Bramante 88/90, 10126 Turin, Italy.ORCID 0000-0002-8180-5075
Noemi GattiDepartment of Life Sciences and Systems Biology, University of Torino, Via Quarello 15/A, 10135 Turin, Italy.
Anna Maria CuffiniDepartment of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
Paola PalmeroDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Turin, Italy.ORCID 0000-0001-7189-2999
Valeria AllizondDepartment of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.ORCID 0000-0003-0585-9247

Funding

Fondazione Cassa di Risparmio di Torino RF = 2019.0588
6 · The paper itself

Abstract

Biomedical implants, an essential part of the medical treatments, still suffer from bacterial infections that hamper patients' recovery and lives. Antibiotics are widely used to cure those infections but brought antibiotic resistance. Essential oils (EOs) demonstrate excellent antimicrobial activity and low resistance development risk. However, EO application in medicine is still quite scarce and almost no research work considers its use in combination with bioresorbable biomaterials, such as the poly(ε-caprolactone) (PCL) polymer. This work aimed to combine the antibacterial properties of EOs and their components, particularly eugenol and cinnamon oil, against

Indexed as

anti-adhesive/anti-bacterial propertiesbiomaterial associated infectionEscherichia coliessential oilspoly(ε-caprolactone)-based biomaterialSaos-2 cells’ cell viability/proliferationS. epidermidisStaphylococcus aureus

Identifiers

PMID36145620
PMCPMC9506294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.