Evidence map›Paper›PMID 36145528›Full record

ReviewPharmaceutics2022

Marine Bioactive Compounds Derived from Macroalgae as New Potential Players in Drug Delivery Systems: A Review.

Bogdan-Stefan Negreanu-Pirjol, Ticuta Negreanu-Pirjol, Dan Razvan Popoviciu, Ruxandra-Elena Anton, Ana-Maria Prelipcean

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Proangiogenic and Collagen-Promoting Effects of a 70% Ethanol Extract ofInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Solid lipid nanoparticles as carriers forFrontiers in aging neuroscience · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bogdan-Stefan Negreanu-PirjolFaculty of Pharmacy, Ovidius University of Constanta, 6, Capitan Aviator Al. Serbanescu Street, Campus, Corp C, 900470 Constanta, Romania.
Ticuta Negreanu-PirjolFaculty of Pharmacy, Ovidius University of Constanta, 6, Capitan Aviator Al. Serbanescu Street, Campus, Corp C, 900470 Constanta, Romania.ORCID 0000-0001-9254-1047
Dan Razvan PopoviciuFaculty of Natural Sciences and Agricultural Sciences, Ovidius University of Constanta, 1, University Alley, Campus, Corp B, 900527 Constanta, Romania.
Ruxandra-Elena AntonCellular and Molecular Biology Department, National Institute of R&D for Biological Sciences, 296, Splaiul Independentei Bvd., 060031 Bucharest, Romania.
Ana-Maria PrelipceanCellular and Molecular Biology Department, National Institute of R&D for Biological Sciences, 296, Splaiul Independentei Bvd., 060031 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The marine algal ecosystem is characterized by a rich ecological biodiversity and can be considered as an unexploited resource for the discovery and isolation of novel bioactive compounds. In recent years, marine macroalgae have begun to be explored for their valuable composition in bioactive compounds and opportunity to obtain different nutraceuticals. In comparison with their terrestrial counterparts, Black Sea macroalgae are potentially good sources of bioactive compounds with specific and unique biological activities, insufficiently used. Macroalgae present in different marine environments contain several biologically active metabolites, including polysaccharides, oligosaccharides, polyunsaturated fatty acids, sterols, proteins polyphenols, carotenoids, vitamins, and minerals. As a result, they have received huge interest given their promising potentialities in supporting antitumoral, antimicrobial, anti-inflammatory, immunomodulatory, antiangiogenic, antidiabetic, and neuroprotective properties. An additional advantage of ulvans, fucoidans and carrageenans is the biocompatibility and limited or no toxicity. This therapeutic potential is a great natural treasure to be exploited for the development of novel drug delivery systems in both preventive and therapeutic approaches. This overview aims to provide an insight into current knowledge focused on specific bioactive compounds, which represent each class of macroalgae e.g., ulvans, fucoidans and carrageenans, respectively, as valuable potential players in the development of innovative drug delivery systems.

Indexed as

bioactive compoundscarrageenansdrug deliveryfucoidansmarine macroalgaeulvans

Identifiers

PMID36145528
PMCPMC9505595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.