Evidence map›Paper›PMID 36145418›Full record

ReviewPathogens (Basel, Switzerland)2022

Effect of Probiotics on Host-Microbiota in Bacterial Infections.

Ascensión Rueda-Robles, Avilene Rodríguez-Lara, Matthew S Meyers, María José Sáez-Lara, Ana I Álvarez-Mercado

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. An 8-Week Course of Bifidobacterium longum 35624Probiotics and antimicrobial proteins · 2025
    Observational
  5. Review
  6. Article
  7. Article
  8. Employment of Spore-Forming Probiotics to Combat Persister Cells ofReports of biochemistry & molecular biology · 2024
    Article
  9. Review
  10. Review
  11. Methicillin ResistantInfection and drug resistance · 2023
    Review
  12. Transcriptomics ofFrontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ascensión Rueda-RoblesDepartment of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, Campus Universitario s/n, 18071 Granada, Spain.ORCID 0000-0003-1048-2448
Avilene Rodríguez-LaraInstitute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, Parque Tecnológico Ciencias de la Salud, University of Granada, 18016 Granada, Spain.
Matthew S MeyersSchool of Medicine Orleans, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-1321-6850
María José Sáez-LaraInstitute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, Parque Tecnológico Ciencias de la Salud, University of Granada, 18016 Granada, Spain.ORCID 0000-0001-7439-9817
Ana I Álvarez-MercadoInstitute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, Parque Tecnológico Ciencias de la Salud, University of Granada, 18016 Granada, Spain.ORCID 0000-0002-8476-9970
Universidad de Granada · ESJohns Hopkins University · US

Funding

Consejería de Salud y Familias RPS 24665
6 · The paper itself

Abstract

Diseases caused by bacteria cause millions of deaths every year. In addition, the problem of resistance to antibiotics is so serious that it threatens the achievements of modern medicine. This is a very important global problem as some bacteria can also develop persistence. Indeed, the persistence of pathogenic bacteria has evolved as a potent survival strategy to overcome host organisms' defense mechanisms. Additionally, chronic or persistent infections may be caused by persisters which could facilitate antibiotic resistance. Probiotics are considered good bacteria. It has been described that the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection. Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria. Bearing in mind that current strategies to avoid bacterial persistence and prevent antibiotic resistance are not effective, other strategies need to be assessed. We have carried out a comprehensive review, which included the reported literature between 2016 and 2021, highlighting the clinical trials that reported the probiotics' potential to regulate gut microbiota after bacterial infection and focusing in particular on the context of antibiotic resistance and persister cells.

Indexed as

antibiotic resistancebacterial persistenceinfectionmicrobiotapathogenic bacteriapersistersprobiotics

Identifiers

PMID36145418
PMCPMC9500725
OpenAlexW4293769624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.