Evidence map›Paper›PMID 36145382›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Albumin-Mediated Size Exclusion Chromatography: The Apparent Molecular Weight of PSMA Radioligands as Novel Parameter to Estimate Their Blood Clearance Kinetics.

Jan-Philip Kunert, Sebastian Fischer, Alexander Wurzer, Hans-Jürgen Wester

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Development of the FirstPharmaceutics · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jan-Philip KunertChair of Pharmaceutical Radiochemistry, TUM Department of Chemistry, Technical University of Munich (TUM), 85748 Garching, Germany.ORCID 0000-0001-6149-7119
Sebastian FischerChair of Pharmaceutical Radiochemistry, TUM Department of Chemistry, Technical University of Munich (TUM), 85748 Garching, Germany.
Alexander WurzerChair of Pharmaceutical Radiochemistry, TUM Department of Chemistry, Technical University of Munich (TUM), 85748 Garching, Germany.
Hans-Jürgen WesterChair of Pharmaceutical Radiochemistry, TUM Department of Chemistry, Technical University of Munich (TUM), 85748 Garching, Germany.
Technical University of Munich · DE

Funding

Deutsche Forschungsgemeinschaft SFB824, projects B11 and Z01
6 · The paper itself

Abstract

A meticulously adjusted pharmacokinetic profile and especially fine-tuned blood clearance kinetics are key characteristics of therapeutic radiopharmaceuticals. We, therefore, aimed to develop a method that allowed the estimation of blood clearance kinetics in vitro. For this purpose,

Indexed as

albuminblood clearancepharmacokineticsplasma protein bindingprostate cancerPSMAradioligand therapyrhPSMAsize exclusion chromatography

Identifiers

PMID36145382
PMCPMC9500755
OpenAlexW4296742288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.