Evidence map›Paper›PMID 36145327›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Novel Bile Salt Stabilized Vesicles-Mediated Effective Topical Delivery of Diclofenac Sodium: A New Therapeutic Approach for Pain and Inflammation.

Tamer M Mahmoud, Mohamed M Nafady, Hanan O Farouk, Dina M Mahmoud, Yasmin M Ahmed, Randa Mohammed Zaki, Doaa S Hamad

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Nasal In-Situ Gels of BrijAAPS PharmSciTech · 2025
    Article
  8. Review
  9. Review
  10. Development of Gentamicin Bilosomes LadenAdvanced pharmaceutical bulletin · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tamer M MahmoudDepartment of Pharmaceutics and Drug Manufacturing, Faculty of Pharmacy, MTI University, Cairo 12055, Egypt.
Mohamed M NafadyDepartment of Pharmaceutics, Faculty of Pharmacy, Nahda University Beni-Suef, Beni-Suef 62764, Egypt.
Hanan O FaroukDepartment of Pharmaceutics, Faculty of Pharmacy, Nahda University Beni-Suef, Beni-Suef 62764, Egypt.
Dina M MahmoudDepartment of Pharmaceutics, Faculty of Pharmacy, Nahda University Beni-Suef, Beni-Suef 62764, Egypt.
Yasmin M AhmedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University Beni-Suef, Beni-Suef 62764, Egypt.ORCID 0000-0001-5145-8458
Randa Mohammed ZakiDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Doaa S HamadDepartment of Pharmaceutics, Faculty of Pharmacy, Nahda University Beni-Suef, Beni-Suef 62764, Egypt.
Nahda University · EGBeni-Suef University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral delivery of diclofenac sodium (DNa), a non-steroidal analgesic, anti-inflammatory drug, is associated with various gastrointestinal side effects. The aim of the research was to appraise the potential of transdermal delivery of DNa using bilosomes as a vesicular carrier (BSVC) in inflamed paw edema. DNa-BSVCs were elaborated using a thin-film hydration technique and optimized using a 3

Indexed as

bilosomesNSAIDspermeation studyrat paw edemathe nuclear factor erythroid 2–related factor 2transdermal drug delivery

Identifiers

PMID36145327
PMCPMC9506322
OpenAlexW4294861065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.