Evidence map›Paper›PMID 36145321›Full record

ReviewPharmaceuticals (Basel, Switzerland)2022

Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD.

Irina Kostareva, Kirill Kirgizov, Elena Machneva, Nadezhda Ustyuzhanina, Nikolay Nifantiev, Yulia Skvortsova, Irina Shubina, Vera Reshetnikova, Timur Valiev, Svetlana Varfolomeeva and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Irina KostarevaResearch Institute of Pediatric Oncology and Hematology of Nikolay Nikolayevich Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.
Kirill KirgizovResearch Institute of Pediatric Oncology and Hematology of Nikolay Nikolayevich Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.
Elena MachnevaRussian Children's Clinical Hospital of the Nikolay Ivanovich Pirogov Russian National Research Medical University, Ministry of Health of Russia, Leninsky Prospect 117, 117997 Moscow, Russia.
Nadezhda UstyuzhaninaLaboratory of Glycoconjugate Chemistry, Nikolay Dmitriyevich Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
Nikolay NifantievLaboratory of Glycoconjugate Chemistry, Nikolay Dmitriyevich Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.ORCID 0000-0002-0727-4050
Yulia SkvortsovaDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia, 1 Samory Mashela St., 117997 Moscow, Russia.
Irina ShubinaResearch Institute of Experimental Diagnostics and Therapy of Tumors of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.ORCID 0000-0002-9374-3158
Vera ReshetnikovaResearch Institute of Experimental Diagnostics and Therapy of Tumors of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.
Timur ValievResearch Institute of Pediatric Oncology and Hematology of Nikolay Nikolayevich Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.
Svetlana VarfolomeevaResearch Institute of Pediatric Oncology and Hematology of Nikolay Nikolayevich Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.
Mikhail KiselevskiyResearch Institute of Experimental Diagnostics and Therapy of Tumors of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia.
Ministry of Health of the Russian Federation · RUNational University of Science and Technology · RUN.D. Zelinsky Institute of Organic Chemistry · RUPirogov Russian National Research Medical University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation . 075-15-2020-777
6 · The paper itself

Abstract

Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD.

Indexed as

graft-versus-host diseasehematopoietic stem cell transplantationnovel agentsoligosaccharides

Identifiers

PMID36145321
PMCPMC9503665
OpenAlexW4294861993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.