ArticlePharmaceuticals (Basel, Switzerland)2022
Zinc Oxide Nanoparticles as Potential Delivery Carrier: Green Synthesis by
Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Sustainable synthesis of mono-, bi- and tri-metallic nanoparticles using endophytic fungi: characterization and different applications.RSC advances · 2026Review
- Antifungal activity of oily core PEGylated PLGA nanocapsules loaded with Penicillium oxalicum fungal extract: in vitro, in vivo, and in silico study.Microbial cell factories · 2026Article
- Green Synthesis of ZnO Nanoparticles: A Sustainable Approach for Wound Care.Nanotechnology, science and applications · 2026Review
- Green Synthesis of Zinc Oxide Nanoparticles and Their Application in Anticancer Drug Delivery - A Review.International journal of nanomedicine · 2026Review
- Green synthesis and functional evaluation of zinc oxide nanoparticles from red dragon fruit peel.Scientific reports · 2025Article
- Mycogenic Fabrication of Zinc Nanoparticles for Their Antifungal Activity AgainstIndian journal of microbiology · 2025Article
- Mycosynthesis of zinc oxide nanoparticles using Mucor racemosus with their antimicrobial, antibiofilm, anticancer and antioxidant activities.Scientific reports · 2025Article
- Synthesis of zinc oxide nanoparticles usingFrontiers in microbiology · 2025Article
- Metal Nanoparticles: From Endophytic Fungi-Mediated Biosynthesis to Their Therapeutic Applications in Oncology.International journal of nanomedicine · 2025Review
- Biosynthesis of bimetallic silver-copper oxide nanoparticles using endophyticFrontiers in microbiology · 2025Article
- In vitro and in vivo efficacy of zinc oxide green nanoparticles against multidrug-resistant Salmonella Typhi.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Advances in antibacterial activity of zinc oxide nanoparticles againstBiomedical reports · 2024Review
- Next-generation probiotics: the upcoming biotherapeutics.Molecular biology reports · 2024Review
- Irisin/PGC-1α/FNDC5 pathway in Parkinson's disease: truth under the throes.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Impact of peripheral blood mononuclear cells preconditioned by activated platelet supernatant in managing gastric mucosal damage induced by zinc oxide nanoparticles in rats.Anatomy & cell biology · 2024Article
- Large-scale production of myco-fabricated ZnO/MnO nanocomposite using endophytic Colonstachys rosea with its antimicrobial efficacy against human pathogens.Scientific reports · 2024Article
- Harnessing biological synthesis: Zinc oxide nanoparticles for plant biotic stress management.Frontiers in chemistry · 2024Review
- Article
- Celecoxib-Loaded Cubosomal Nanoparticles as a Therapeutic Approach forMicroorganisms · 2023Article
- Protective Role of Betulinic Acid against Cisplatin-Induced Nephrotoxicity and Its Antibacterial Potential toward Uropathogenic Bacteria.Pharmaceuticals (Basel, Switzerland) · 2023Article
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Authors and funding
6 authors.
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Abstract
We aimed to synthesize zinc oxide nanoparticles (ZnO NPs) using the endophytic fungal extract of Aspergillus niger. The prepared ZnO NPs were characterized, and their in vitro and in vivo antibacterial activity was investigated. Isolated endophytic fungus identification was carried out using 18S rRNA. A. niger endophytic fungal extract was employed for the green synthesis of ZnO NPs. The in vitro antibacterial activity of the prepared ZnO NPs was elucidated against Staphylococcus aureus using the broth microdilution method and quantitative real-time polymerase chain reaction (qRT-PCR). Additionally, the in vivo antibacterial activity was elucidated using a systemic infection model in mice. The biosynthesized ZnO NPs showed a maximum optical density at 380 nm with characteristic peaks on the Fourier-transform infrared spectrum. The X-ray diffraction pattern was highly matched with a standard platform of zinc oxide crystals. Energy-dispersive X-ray analysis confirmed that the main composition of nanoparticles was zinc and oxygen atoms. Scanning and transmission electron microscopies showed spherical geometry with a smooth surface. Zeta potential measurements (26.6 ± 0.56 mV) verified the adequate stability of ZnO NPs. Minimum inhibitory concentrations of ZnO NPs against S. aureus isolates ranged from 8 to 128 µg/mL. Additionally, ZnO NPs revealed antibiofilm activity, resulting in the downregulation of the tested biofilm genes in 29.17% of S. aureus isolates. Regarding the in vivo experiment, ZnO NPs reduced congestion and fibrosis in liver and spleen tissues. They also improved liver function, increased the survival rate, and significantly decreased inflammatory markers (p < 0.05). ZnO NPs synthesized by A. niger endophytic fungus revealed a promising in vivo and in vitro antibacterial action against S. aureus isolates.
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