Evidence map›Paper›PMID 36145242›Full record

ArticleNutrients2022

Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.

Manoja K Brahma, Peng Xiao, Madalina Popa, Javier Negueruela, Valerie Vandenbempt, Stéphane Demine, Alessandra K Cardozo, Esteban N Gurzov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Manoja K BrahmaSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Peng XiaoInflammatory and Cell Death Signaling in Diabetes, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Madalina PopaSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Javier NegueruelaSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Valerie VandenbemptSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Stéphane DemineSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Alessandra K CardozoInflammatory and Cell Death Signaling in Diabetes, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Esteban N GurzovSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Université Libre de Bruxelles · BE

Funding

European Research Council (ERC) Consolidator GA817940Fonds National de la Recherche Scientifique (FNRS) 33650793, 35275350, 30826052, PhD Aspirant scholarship (V.V.), Research Associate (E.N.G.)Juvenile Diabetes Research Foundation CDA-2019-758-A-N
6 · The paper itself

Abstract

The loss of functional pancreatic β-cell mass is an important hallmark of both type 1 and type 2 diabetes. The RNA-binding protein NOVA1 is expressed in human and rodent pancreatic β-cells. Previous in vitro studies indicated that NOVA1 is necessary for glucose-stimulated insulin secretion and its deficiency-enhanced cytokine-induced apoptosis. Moreover, Bim, a proapoptotic protein, is differentially spliced and potentiates apoptosis in NOVA1-deficient β-cells in culture. We generated two novel mouse models by Cre-Lox technology lacking Nova1 (βNova1

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Insulin-Secreting CellsAnimalsBcl-2-Like Protein 11Blood GlucoseCytokinesDiet, High-FatGlucoseHumansInsulinMiceNeuro-Oncological Ventral AntigenObesityRNA-Binding ProteinsStreptozocinBcl2l11 protein, mouseBcl-2-Like Protein 11Blood GlucoseCytokinesGlucoseInsulinNeuro-Oncological Ventral AntigenNOVA1 protein, humanNova1 protein, mouseRNA-Binding ProteinsStreptozocinBimdiabetesNova1obesitypancreatic β-cells

Identifiers

PMID36145242
PMCPMC9500891
OpenAlexW4296365105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.