Evidence map›Paper›PMID 36145194›Full record

ArticleNutrients2022

Associations of Human Milk Oligosaccharides with Infant Brain Tissue Organization and Regional Blood Flow at 1 Month of Age.

Paige K Berger, Ravi Bansal, Siddhant Sawardekar, Chloe Yonemitsu, Annalee Furst, Hailey E Hampson, Kelsey A Schmidt, Tanya L Alderete, Lars Bode, Michael I Goran and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Paige K BergerDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1670-5147
Ravi BansalDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Siddhant SawardekarDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Chloe YonemitsuDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-8729-8094
Annalee FurstDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, CA 92093, USA.
Hailey E HampsonDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Kelsey A SchmidtDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Tanya L AldereteDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.ORCID 0000-0002-7751-9543
Lars BodeDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, CA 92093, USA.
Michael I GoranDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0002-6897-6961
Bradley S PetersonDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0001-5737-225X
Children's Hospital of Los Angeles · USUniversity of California San Diego · USBrigham and Women's Hospital · USUniversity of Colorado Boulder · US

Funding

Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and ObesityR01DK110793 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC, PETERSON, BRADLEY S · 2017 to 2024
$6.0M
Brain-Imaging Markers of Neurotoxicity and Long-Term Outcomes after CAR-T Cell TherapyR01CA274137 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Ravi Bansal, Deepa Bhojwani · 2023 to 2026
$2.8M
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in AdolescenceR00ES027853 · NIEHS · UNIVERSITY OF COLORADO · PI ALDERETE, TANYA LYNN · 2018 to 2020
$721k
Role of Human Milk Oligosaccharides on Brain Development in Preterm InfantsR00HD098288 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BERGER, PAIGE KIMBERLY · 2022 to 2024
$686k
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD098288NCI NIH HHS R01 CA274137NICHD NIH HHS R00 HD098288NIDDK NIH HHS DK110793NIDDK NIH HHS R01 DK110793NIEHS NIH HHS R00 ES027853
6 · The paper itself

Abstract

Animal studies have shown that human milk oligosaccharides (HMOs) are important in early brain development, yet their roles have not been assessed in humans. The purpose of this study was to determine the associations of HMOs with MRI indices of tissue microstructure and regional cerebral blood flow (rCBF) in infants. Mother-infant pairs (N = 20) were recruited at 1 month postpartum. Milk was assayed for the concentrations of the HMOs 2'-fucosyllactose (2'FL), 3-fucosyllactose (3FL), 3'-sialyllactose (3'SL), and 6'-sialyllactose (6'SL). Diffusion and arterial spin labeling measures were acquired using a 3.0-Tesla MRI scanner. Multiple linear regression was used to assess the voxel-wise associations of HMOs with fractional anisotropy (FA), mean diffusivity (MD), and rCBF values across the brain. After adjusting for pre-pregnancy BMI, sex, birthweight, and postmenstrual age at time of scan, a higher 2'FL concentration was associated with reduced FA, increased MD, and reduced rCBF in similar locations within the cortical mantle. Higher 3FL and 3'SL concentrations were associated with increased FA, reduced MD, and increased rCBF in similar regions within the developing white matter. The concentration of 6'SL was not associated with MRI indices. Our data reveal that fucosylated and sialylated HMOs differentially associate with indices of tissue microstructure and rCBF, suggesting specific roles for 2'FL, 3FL, and 3'SL in early brain maturation.

Indexed as

Milk, HumanOligosaccharidesAnimalsBrainFemaleHumansInfantMothersPregnancyRegional Blood FlowOligosaccharidesbrain developmentbreastfeedinginfancylactationmagnetic resonance imagingoligosaccharides

Identifiers

PMID36145194
PMCPMC9501015
OpenAlexW4296360437

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.