Evidence map›Paper›PMID 36145109›Full record

ArticleNutrients2022

Variability in Skeletal Muscle Protein Synthesis Rates in Critically Ill Patients.

Inga Tjäder, Maria Klaude, Ali Ait Hssain, Christelle Guillet, Inger Nennesmo, Jan Wernerman, Olav Rooyackers

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Inga TjäderDepartment of Perioperative Medicine and Intensive Care, Karolinska University Hospital, 14186 Huddinge, Sweden.
Maria KlaudeDepartment of Perioperative Medicine and Intensive Care, Karolinska University Hospital, 14186 Huddinge, Sweden.
Ali Ait HssainDepartment of Intensive Care Unit, University Hospital of Clermont-Ferrand, 63100 Clermont-Ferrand, France.
Christelle GuilletUnité de Nutrition Humaine, Clermont Université, Université d'Auvergne, INRA, 63001 Clermont-Ferrand, France.
Inger NennesmoDepartment of Pathology, Karolinska Institutet, 17177 Stockholm, Sweden.
Jan WernermanDepartment of Perioperative Medicine and Intensive Care, Karolinska University Hospital, 14186 Huddinge, Sweden.
Olav RooyackersDivision of Anesthesiology and Intensive Care, CLINTEC, Karolinska Institutet, 14152 Huddinge, Sweden.ORCID 0000-0002-3391-5448
Karolinska University Hospital · SEKarolinska Institutet · SECentre Hospitalier Universitaire de Clermont-Ferrand · FRUniversité Clermont Auvergne · FR

Funding

Stockholm County Council 130368Swedish Research Council 04210
6 · The paper itself

Abstract

(1) Background: Muscle protein synthesis in critically ill patients is, on average, normal despite dramatic muscle loss, but the variation is much larger than in controls. Here, we evaluate if this variation is due to 1) heterogeneity in synthesis rates, 2) morphological variation or infiltrating cells, or 3) heterogeneity in the synthesis of different protein fractions. (2) Methods: Muscle biopsies were taken from both legs of critically ill patients (

Indexed as

ActinsCritical IllnessHumansMitochondrial ProteinsMuscle ProteinsMuscle, SkeletalMyosinsActinsMitochondrial ProteinsMuscle ProteinsMyosinsmultiple organ failuremuscle morphologyprotein synthesisstable isotopes

Identifiers

PMID36145109
PMCPMC9501828
OpenAlexW4296588507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.