ArticleNanomaterials (Basel, Switzerland)2022
Effective Method for a Graphene Oxide with Impressive Selectivity in Carboxyl Groups.
Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Biosensing applications of gold-functionalized carbon-based composites.Bioprocess and biosystems engineering · 2026Review
- Bioactive siRNA-Based Liposomes Promoted Tendon-Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Anisotropy of Electrical and Thermal Conductivity in High-Density Graphite Foils.Nanomaterials (Basel, Switzerland) · 2024Article
- Application of Graphene-Based Materials.Nanomaterials (Basel, Switzerland) · 2023Article
- Engineering Functional Graphenic Materials for Bone Repair.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The development of new applications of graphene oxide in the biomedical field requires the covalent bonding of bioactive molecules to a sheet skeleton. Obtaining a large carboxyl group population over the surface is one of the main targets, as carboxyl group concentration in conventional graphene oxide is low among a majority of non-useful sp3-C-based functionalities. In the present work, we propose a selective method that yields an impressive increase in carboxyl group population using single-layer, thermally reduced graphene oxide as a precursor in a conventional Hummers-Offemann reaction. When starting with a reduced graphene oxide with no interlayer registry, sulfuric acid cannot form a graphite intercalated compound. Then, potassium permanganate attacks in in-plane (vacancies or holes) structural defects, which are numerous over a thermally reduced graphene oxide, as well as in edges, yielding majorly carboxyl groups without sheet cutting and unzipping, as no carbon dot formation was observed. A single-layer precursor with no ordered stacking prevents the formation of an intercalated compound, and it is this mechanism of the potassium permanganate that results in carboxyl group formation and the hydrophilic character of the compound.
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Registered trials
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