Evidence map›Paper›PMID 36144820›Full record

ArticleMolecules (Basel, Switzerland)2022

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives.

Rafaqat Hussain, Hayat Ullah, Fazal Rahim, Maliha Sarfraz, Muhammad Taha, Rashid Iqbal, Wajid Rehman, Shoaib Khan, Syed Adnan Ali Shah, Sajjad Hyder and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Rafaqat HussainDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Hayat UllahDepartment of Chemistry, University of Okara, Okara 56300, Pakistan.ORCID 0000-0003-3833-1457
Fazal RahimDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Maliha SarfrazDepartment of Zoology, Wildlife and Fisheries, University of Agriculture Faisalabad, Sub-Campus Toba Tek Singh, Punjab 36050, Pakistan.
Muhammad TahaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0003-3047-9289
Rashid IqbalDepartment of Agronomy, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur Pakistan, Bahawalpur 63100, Pakistan.ORCID 0000-0003-0473-889X
Wajid RehmanDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.ORCID 0000-0003-0128-0377
Shoaib KhanDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Syed Adnan Ali ShahFaculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.ORCID 0000-0002-8142-5013
Sajjad HyderDepartment of Botany, Government College Women University, Sialkot 51310, Pakistan.ORCID 0000-0002-6094-5650
Majid AlhomraniDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0001-9798-0962
Abdulhakeem S AlamriDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0003-3174-0434
Osama AbdulazizDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Mahmoud A AbdelazizDepartment of Chemistry, Faculty of Science, University of Tabuk, P.O. Box 741, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-1317-0653
Hazara University · PKTaif University · SAGovernment College Women University SialkotImam Abdulrahman Bin Faisal University · SAIslamia University of Bahawalpur · PKUniversiti Teknologi MARA · MYUniversity of Agriculture Faisalabad · PKUniversity of Okara · PKUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twenty-four analogues of benzimidazole-based thiazoles (

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsAcetylcholinesteraseAmino AcidsBenzimidazolesButyrylcholinesteraseDonepezilHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipThiazolesAcetylcholinesteraseAmino AcidsBenzimidazolesButyrylcholinesteraseCholinesterase InhibitorsDonepezilThiazolesacetylcholinesterasebenzimidazolebutyrylcholinesterasemolecular dockingstructure-activity relationshipSynthesisthiazole

Identifiers

PMID36144820
PMCPMC9504419
OpenAlexW4296354130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.