Evidence map›Paper›PMID 36144805›Full record

ArticleMolecules (Basel, Switzerland)2022

The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow.

Roman Verkhovskii, Alexey Ermakov, Oleg Grishin, Mikhail A Makarkin, Ilya Kozhevnikov, Mikhail Makhortov, Anastasiia Kozlova, Samia Salem, Valery Tuchin, Daniil Bratashov

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Roman VerkhovskiiScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0003-1830-4582
Alexey ErmakovScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0001-8105-5932
Oleg GrishinScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0001-7463-6536
Mikhail A MakarkinScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0003-4633-6602
Ilya KozhevnikovScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.
Mikhail MakhortovScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.
Anastasiia KozlovaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0002-9336-0317
Samia SalemScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.
Valery TuchinScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0001-7479-2694
Daniil BratashovScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia.ORCID 0000-0002-2096-4478

Funding

Russian Science Foundation 18-19-00354
6 · The paper itself

Abstract

A promising approach to targeted drug delivery is the remote control of magnetically sensitive objects using an external magnetic field source. This method can assist in the accumulation of magnetic carriers in the affected area for local drug delivery, thus providing magnetic nanoparticles for MRI contrast and magnetic hyperthermia, as well as the magnetic separation of objects of interest from the bloodstream and liquid biopsy samples. The possibility of magnetic objects' capture in the flow is determined by the ratio of the magnetic field strength and the force of viscous resistance. Thus, the capturing ability is limited by the objects' magnetic properties, size, and flow rate. Despite the importance of a thorough investigation of this process to prove the concept of magnetically controlled drug delivery, it has not been sufficiently investigated. Here, we studied the efficiency of polyelectrolyte capsules' capture by the external magnetic field source depending on their size, the magnetic nanoparticle payload, and the suspension's flow rate. Additionally, we estimated the possibility of magnetically trapping cells containing magnetic capsules in flow and evaluated cells' membrane integrity after that. These results are required to prove the possibility of the magnetically controlled delivery of the encapsulated medicine to the affected area with its subsequent retention, as well as the capability to capture magnetically labeled cells in flow.

Indexed as

Drug Delivery SystemsMagneticsCapsulesMagnetic FieldsPolyelectrolytesCapsulesPolyelectrolytesflow cytometryinternalization of microcapsulesmagnetic cell sortingmagnetic drug deliverymagnetic separationpolyelectrolyte microcapsulestargeted drug delivery

Identifiers

PMID36144805
PMCPMC9501256

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.