Evidence map›Paper›PMID 36144686›Full record

ArticleMolecules (Basel, Switzerland)2022

Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones.

Zhanyong Wang, Ting Yang, Dongfang Liu, Rongxiang Chen, Nan Wang, Hong Liu, Jiarong Li, Kaikai Wang, Hongxin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhanyong WangSchool of Pharmacy, Xinxiang University, Xinxiang 453003, China.
Ting YangNursing College, Xinxiang University, Xinxiang 453003, China.
Dongfang LiuXinxiang Runyu Material Co., Ltd., Xinxiang 453003, China.
Rongxiang ChenSchool of Pharmacy, Xinxiang University, Xinxiang 453003, China.
Nan WangSchool of Pharmacy, Xinxiang University, Xinxiang 453003, China.
Hong LiuSchool of Pharmacy, Xinxiang University, Xinxiang 453003, China.
Jiarong LiSchool of Pharmacy, Xinxiang University, Xinxiang 453003, China.
Kaikai WangSchool of Pharmacy, Xinxiang University, Xinxiang 453003, China.
Hongxin LiuCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.

Funding

National Natural Science Foundation of China 21801214the Foundation of 2021 Wenzhou Association for Science and Technology Service innovation project kjfw35the Foundation of Zhejiang Educational Committee Y201839490The Higher Education Institution Key Research Project Plan of Henan Province of China 22B150015the Natural Science Foundation of Henan Province 202300410016the Program for Youth Backbone Teacher Training in University of Henan Province 2021GGJS163
6 · The paper itself

Abstract

An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael-aldol-lactonization leading to differential product formation was achieved by different NHCs catalysis.

Indexed as

BenzofuransHeterocyclic CompoundsAldehydesCatalysisLactonesMolecular StructureSpiro CompoundsStereoisomerismAldehydesBenzofuransHeterocyclic CompoundsLactonesspirobenzofuranSpiro CompoundsN-heterocyclic carbenesSpirobenzofuran-3-onethree-component reactionα,β-unsaturated acylazoliumsδ-Lactones

Identifiers

PMID36144686
PMCPMC9503435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.