Evidence map›Paper›PMID 36144674›Full record

ArticleMolecules (Basel, Switzerland)2022

Cold Atmospheric Plasma Activates Selective Photothermal Therapy of Cancer.

Jiamin Qin, Jingqi Zhang, Guojuan Fan, Xiaoxia Wang, Yuzhong Zhang, Ling Wang, Yapei Zhang, Qingfa Guo, Jin Zhou, Weifen Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jiamin QinSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.
Jingqi ZhangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.
Guojuan FanDepartment of Skin, Weifang Hospital of Traditional Chinese Medicine, Weifang 261000, China.
Xiaoxia WangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.
Yuzhong ZhangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.
Ling WangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.
Yapei ZhangDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA.
Qingfa GuoCollege of Chemical Engineering and Environmental Chemistry, Weifang University, Weifang 261061, China.
Jin ZhouSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.ORCID 0000-0001-6761-3408
Weifen ZhangSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.
Jinlong MaSchool of Pharmacy, Weifang Medical University, Weifang 261053, China.ORCID 0000-0002-4321-9024
Weifang Medical University · CNWeifang Chinese Medicine Hospital · CNWeifang University · CN

Funding

National Natural Science Foundation of China 81973671Natural Science Foundation of Shandong Province ZR2019BB071
6 · The paper itself

Abstract

Due to the body's systemic distribution of photothermal agents (PTAs), and to the imprecise exposure of lasers, photothermal therapy (PTT) is challenging to use in treating tumor sites selectively. Striving for PTT with high selectivity and precise treatment is nevertheless important, in order to raise the survival rate of cancer patients and lower the likelihood of adverse effects on other body sections. Here, we studied cold atmospheric plasma (CAP) as a supplementary procedure to enhance selectivity of PTT for cancer, using the classical photothermic agent's gold nanostars (AuNSs). In in vitro experiments, CAP decreases the effective power of PTT: the combination of PTT with CAP at lower power has similar cytotoxicity to that using higher power irradiation alone. In in vivo experiments, combination therapy can achieve rapid tumor suppression in the early stages of treatment and reduce side effects to surrounding normal tissues, compared to applying PTT alone. This research provides a strategy for the use of selective PTT for cancer, and promotes the clinical transformation of CAP.

Indexed as

NeoplasmsPhotochemotherapyPlasma GasesCell Line, TumorGoldHumansPhototherapyPhotothermal TherapyGoldPlasma Gasescancer treatmentcold atmospheric plasmagold nanostarsselective photothermal therapy

Identifiers

PMID36144674
PMCPMC9502787
OpenAlexW4296005320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.