Evidence map›Paper›PMID 36144662›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach.

Kailey A Wyman, Adel S Girgis, Pragnakiran S Surapaneni, Jade M Moore, Noura M Abo Shama, Sara H Mahmoud, Ahmed Mostafa, Reham F Barghash, Zou Juan, Radha D Dobaria and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kailey A WymanDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Adel S GirgisDepartment of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0003-4407-9745
Pragnakiran S SurapaneniDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Jade M MooreDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Noura M Abo ShamaCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
Sara H MahmoudCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
Ahmed MostafaCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.ORCID 0000-0002-2878-5714
Reham F BarghashDepartment of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0003-2731-9970
Zou JuanDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Radha D DobariaDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Ahmad J AlmalkiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-1333-980X
Tarek S IbrahimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-3049-4617
Siva S PandaDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3668-104X

Funding

King Abdulaziz University RG-34-166-43
6 · The paper itself

Abstract

We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Antiviral AgentsHumansMolecular Docking SimulationAntiviral Agentshealthcareindolemolecular modelingquinolinerhodanineSARS-CoV-2

Identifiers

PMID36144662
PMCPMC9501548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.