Evidence map›Paper›PMID 36144649›Full record

ArticleMolecules (Basel, Switzerland)2022

Total Synthesis of the Four Stereoisomers of Cyclo(l-Trp-l-Arg) Raises Uncertainty of the Structures of the Natural Products and Invalidates Their Promising Antimicrobial Activities.

Dan Chen, Daniel J Park, Melissa M Cadelis, Hana Douafer, Marie Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R Copp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Dan ChenSchool of Chemical Sciences, The University of Auckland, Waipapa Taumata Rau, Private Bag 92019, Auckland 1142, New Zealand.
Daniel J ParkSchool of Chemical Sciences, The University of Auckland, Waipapa Taumata Rau, Private Bag 92019, Auckland 1142, New Zealand.
Melissa M CadelisSchool of Chemical Sciences, The University of Auckland, Waipapa Taumata Rau, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0003-3883-0109
Hana DouaferUMR MD1 "Membranes et Cibles Thérapeutiques", U1261 INSERM, Faculté de Pharmacie, Aix-Marseille Universite, 27 bd Jean Moulin, 13385 Marseille, France.
Marie Lise Bourguet-KondrackiLaboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
Jean Michel BrunelUMR MD1 "Membranes et Cibles Thérapeutiques", U1261 INSERM, Faculté de Pharmacie, Aix-Marseille Universite, 27 bd Jean Moulin, 13385 Marseille, France.ORCID 0000-0002-9355-8980
Brent R CoppSchool of Chemical Sciences, The University of Auckland, Waipapa Taumata Rau, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0001-5492-5269
University of Auckland · NZInserm · FRCentre National de la Recherche Scientifique · FR

Funding

Catalyst: Seeding Dumont d'Urville NZ-France Science & Technology Support Programme 19-UOA-057-DDUWellcome Trust
6 · The paper itself

Abstract

New therapeutic options to combat the growing incidence of antimicrobial resistance are urgently needed. A 2015 publication reported the isolation and biological evaluation of two diketopiperazine natural products, cyclo(l-Trp-l-Arg) (CDP 2) and cyclo(d-Trp-d-Arg) (CDP 3), from an

Indexed as

Anti-Infective AgentsBiological ProductsAmpicillinAnti-Bacterial AgentsDiketopiperazinesDipeptidesGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsPeptides, CyclicStereoisomerismUncertaintyAmpicillinAnti-Bacterial AgentsAnti-Infective AgentsBiological ProductsDiketopiperazinesDipeptidesPeptides, Cyclicantibiotic enhancementantimicrobialcyclo(Trp-Arg)diketopiperazinenatural productstructure revisionsynthesis

Identifiers

PMID36144649
PMCPMC9501421
OpenAlexW4296007379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.