Evidence map›Paper›PMID 36144618›Full record

ArticleMolecules (Basel, Switzerland)2022

Multispectral and Molecular Docking Studies Reveal Potential Effectiveness of Antidepressant Fluoxetine by Forming π-Acceptor Complexes.

Ahmed Gaber, Walaa F Alsanie, Majid Alhomrani, Abdulhakeem S Alamri, Hussain Alyami, Sonam Shakya, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Abdulwahab Alamri and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Exploration of Potential Antidepressant Active Ingredients ofJournal of analytical methods in chemistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Ahmed GaberDepartment of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-8297-935X
Walaa F AlsanieCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Majid AlhomraniCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-9798-0962
Abdulhakeem S AlamriCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-3174-0434
Hussain AlyamiCollege of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-5792-6638
Sonam ShakyaDepartment of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202002, India.ORCID 0000-0002-3581-8545
Hamza HabeeballahDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences in Rabigh, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-0116-3701
Heba A AlkhatabiDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Raed I FelimbanDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0853-2162
Abdulwahab AlamriDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, P.O. Box 2240, Hail 55476, Saudi Arabia.
Abdulhameed Abdullah AlhabeebNational Centre for Mental Health Promotion, P.O. Box 95459, Riyadh 11525, Saudi Arabia.
Bassem M RaafatDepartment of Radiological Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Moamen S RefatDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-5602-5096
Taif University · SAKing Abdulaziz University · SAAligarh Muslim University · INCentre for Mental Health · GB

Funding

Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia 1-441-121
6 · The paper itself

Abstract

Poor mood, lack of pleasure, reduced focus, remorse, unpleasant thoughts, and sleep difficulties are all symptoms of depression. The only approved treatment for children and adolescents with major depressive disorder (MDD) is fluoxetine hydrochloride (FXN), a serotonin selective reuptake inhibitor antidepressant. MDD is the most common cause of disability worldwide. In the present research, picric acid (PA); dinitrobenzene; p-nitro benzoic acid; 2,6-dichloroquinone-4-chloroimide; 2,6-dibromoquinone-4-chloroimide; and 7,7',8,8'-tetracyanoquinodimethane were used to make 1:1 FXN charge-transfer compounds in solid and liquid forms. The isolated complexes were then characterized by elemental analysis, conductivity, infrared, Raman, and

Indexed as

FluoxetineMajor Depressive DisorderAdolescentAntidepressive AgentsBenzoic AcidChildDinitrobenzenesDopamineHumansMolecular Docking SimulationPicratesSelective Serotonin Reuptake InhibitorsSerotoninAntidepressive AgentsBenzoic AcidDinitrobenzenesDopamineFluoxetinePicratespicric acidSelective Serotonin Reuptake InhibitorsSerotoninfluoxetine HClmajor depressive disordermolecular dockingspectroscopyπ-acceptor complexes

Identifiers

PMID36144618
PMCPMC9505585
OpenAlexW4296012603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.