Enantioselective Cyclopropanation Catalyzed by Gold(I)-Carbene Complexes.

Zita Szabo, Sophia Ben Ahmed, Zoltan Nagy, Attila Paczal, Andras Kotschy

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 92% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zita SzaboServier Research Institute of Medicinal Chemistry, Záhony u. 7., 1031 Budapest, Hungary.

Sophia Ben AhmedServier Research Institute of Medicinal Chemistry, Záhony u. 7., 1031 Budapest, Hungary.

Zoltan NagyServier Research Institute of Medicinal Chemistry, Záhony u. 7., 1031 Budapest, Hungary.

Attila PaczalServier Research Institute of Medicinal Chemistry, Záhony u. 7., 1031 Budapest, Hungary.

Andras KotschyServier Research Institute of Medicinal Chemistry, Záhony u. 7., 1031 Budapest, Hungary.ORCID 0000-0002-7675-3864

Funding

National Research, Development and Innovation Fund of Hungary FIEK_16-1-2016-0005

6 · The paper itself

Abstract

The formation of polysubstituted cyclopropane derivatives in the gold(I)-catalyzed reaction of olefins and propargylic esters is a potentially useful transformation to generate diversity, therefore any method in which its stereoselectivity could be controlled is of significant interest. We prepared and tested a series of chiral gold(I)-carbene complexes as a catalyst in this transformation. With a systematic optimization of the reaction conditions, we were able to achieve high enantioselectivity in the test reaction while the

Indexed as

AlkenesGoldAlkynesCatalysisCyclopropanesEstersMethaneStereoisomerismAlkenesAlkynescarbeneCyclopropanesEstersGoldMethaneasymmetric synthesiscarbene complexescyclopropanationgold catalysis

Identifiers

PMID36144540

DOI10.3390/molecules27185805

PMCPMC9501563

OpenAlexW4295007909

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.