Evidence map›Paper›PMID 36144516›Full record

ArticleMolecules (Basel, Switzerland)2022

Silver Nanoparticles Conjugated with Colistin Enhanced the Antimicrobial Activity against Gram-Negative Bacteria.

Poowadon Muenraya, Somchai Sawatdee, Teerapol Srichana, Apichart Atipairin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

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  19. Multi-Functional Electrospun AgNOMolecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Poowadon MuenrayaSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.ORCID 0000-0002-9465-4085
Somchai SawatdeeSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.
Teerapol SrichanaDrug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.ORCID 0000-0002-4772-2276
Apichart AtipairinSchool of Pharmacy, Walailak University, Nakhon Si Thammarat 80161, Thailand.ORCID 0000-0003-2280-6649
Walailak University · THPrince of Songkla University · TH

Funding

Walailak University Graduate Research Fund Contract no. CGS-RF-2021/01
6 · The paper itself

Abstract

Colistin is a potent peptide antibiotic that is effective against Gram-negative bacteria. However, nephrotoxicity limited its clinical use. Silver nanoparticles (AgNPs) have gained attention as a potential antimicrobial agent and nanodrug carrier. The conjugation of antibiotics and AgNPs has been found to increase the activity and decrease drug toxicity. In this study, colistin was conjugated with AgNPs (Col-AgNPs), which was confirmed by Fourier-transform infrared (FT-IR) and energy-dispersive X-ray (EDX) spectra. The optimized Col-AgNPs had the proper characteristics, including spherical shape, monodispersity, nanosized particle, high surface charge, and good stability. The powder X-ray diffraction (PXRD) pattern supported the crystallinity of Col-AgNPs and AgNPs. The drug loading of Col-AgNPs was 11.55 ± 0.93%. Col-AgNPs had higher activity against Gram-negative bacteria (

Indexed as

Anti-Infective AgentsMetal NanoparticlesAnti-Bacterial AgentsColistinEscherichia coliGram-Negative BacteriaHumansMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionPowdersSilverSpectroscopy, Fourier Transform InfraredAnti-Bacterial AgentsAnti-Infective AgentsColistinPowdersSilverantimicrobial activitycharacterizationcolistincytotoxicityhemolysissilver nanoparticle

Identifiers

PMID36144516
PMCPMC9505607
OpenAlexW4295007917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.