Evidence map›Paper›PMID 36144422›Full record

ArticleMicroorganisms2022

Bacterial Compositional Shifts of Gut Microbiomes in Patients with Rheumatoid Arthritis in Association with Disease Activity.

Nagwan G El Menofy, Mohammed Ramadan, Eman R Abdelbary, Hatem G Ibrahim, Adel I Azzam, Mohamed M Ghit, Ahmed S Ezz, Yasser A Gazar, Mohammed Salah

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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  17. Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritisFrontiers in cellular and infection microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nagwan G El MenofyMicrobiology and Immunology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0001-6928-9170
Mohammed RamadanMicrobiology and Immunology Department, Faculty of Pharmacy Al-Azhar University-Assiut Branch, Assiut 71526, Egypt.
Eman R AbdelbaryMicrobiology and Immunology Department, Faculty of Pharmacy Al-Azhar University-Assiut Branch, Assiut 71526, Egypt.
Hatem G IbrahimDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.ORCID 0000-0002-2906-9162
Adel I AzzamDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.ORCID 0000-0001-6619-8855
Mohamed M GhitDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.ORCID 0000-0002-5697-8505
Ahmed S EzzDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.
Yasser A GazarDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo 11651, Egypt.ORCID 0000-0003-3507-6470
Mohammed SalahMicrobiology and Immunology Department, Faculty of Pharmacy, Port Said University, Port Said City 42526, Egypt.
Al-Azhar University · EGPort Said University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic inflammatory disabling autoimmune disorder. Little is known regarding the association between the gut microbiome and etiopathogenesis of RA. We aimed to dissect the differences in gut microbiomes associated with RA in comparison to healthy individuals and, in addition, to identify the shifts in the bacterial community in association with disease activity; Methods: In order to identify compositional shifts in gut microbiomes of RA patients, V3-V4 hypervariable regions of 16S rRNA were sequenced using Illumina MiSeq. In total, sixty stool samples were collected from 45 patients with RA besides 15 matched healthy subjects; Results: Notably, RA microbiomes were significantly associated with diverse bacterial communities compared with healthy individuals. Likewise, a direct association between bacterial diversity and disease activity was detected in RA patients (Kruskal Wallis;

Indexed as

16S rRNA gene sequencingAdlercreutziaautoimmune diseaseDAS28gut microbiomeMegasphaerarheumatoid arthritis

Identifiers

PMID36144422
PMCPMC9505928
OpenAlexW4296014435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.