Evidence map›Paper›PMID 36144194›Full record

ArticleMetabolites2022

The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Ruifang Li-Gao, Kirk Grubbs, Alain G Bertoni, Kristi L Hoffman, Joseph F Petrosino, Gautam Ramesh, Martin Wu, Jerome I Rotter, Yii-Der Ida Chen, Anne M Evans and 6 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease.Diabetes/metabolism research and reviews · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-0650-1351
Kirk GrubbsMetabolon, Inc., Morrisville, NC 27560, USA.
Alain G BertoniDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Kristi L HoffmanAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Joseph F PetrosinoAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Gautam RameshSchool of Medicine, University of California San Diego, La Jolla, CA 92161, USA.ORCID 0000-0003-4064-3353
Martin WuDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0003-3093-4077
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.ORCID 0000-0001-7191-1723
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Anne M EvansMetabolon, Inc., Morrisville, NC 27560, USA.
Richard J RobinsonMetabolon, Inc., Morrisville, NC 27560, USA.
Laura SommervilleMetabolon, Inc., Morrisville, NC 27560, USA.ORCID 0000-0002-2556-1651
Dennis Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0001-6364-5103
Gregory A MichelottiMetabolon, Inc., Morrisville, NC 27560, USA.
Patricia A SheridanMetabolon, Inc., Morrisville, NC 27560, USA.
Metabolon (United States) · USBaylor College of Medicine · USLeiden University Medical Center · NLUCLA Medical Center · USCedars-Sinai Medical Center · USUniversity of California San Diego · USUniversity of Virginia · USWake Forest University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Impact of the gut microbiome and diet on change in insulin homeostasis and cardiometabolic riskR01DK109588 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI GOODARZI, MARK, PETROSINO, JOSEPH FRANK · 2017 to 2021
$3.1M
NCATS NIH HHS UL1 TR001442NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1TR001881NHLBI NIH HHS R01 HL105756NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK109588NIH HHS R01DK109588
6 · The paper itself

Abstract

Non-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associations between ABO haplotypes and insulin-related traits as well as potential mediating pathways. We assessed insulin homeostasis in African Americans (AAs;

Indexed as

ABO blood typegut microbiomeinsulin homeostasismediation analysismetabolites

Identifiers

PMID36144194
PMCPMC9505353
OpenAlexW4293217320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.