Evidence map›Paper›PMID 36144179›Full record

ArticleMetabolites2022

Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients.

Sultan S Abdelhamid, Jacob Scioscia, Yoram Vodovotz, Junru Wu, Anna Rosengart, Eunseo Sung, Syed Rahman, Robert Voinchet, Jillian Bonaroti, Shimena Li and 6 more

Abstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Adolescent trauma and alcohol: increased risk for severe head injury and organ dysfunction-insights from the TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  7. Article
  8. Article
  9. New insights into metabolism dysregulation after TBI.Journal of neuroinflammation · 2024
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sultan S AbdelhamidDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-8395-2637
Jacob SciosciaDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yoram VodovotzDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Junru WuDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Anna RosengartCenter for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Eunseo SungCenter for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Syed RahmanCenter for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Robert VoinchetDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jillian BonarotiDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Shimena LiDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jennifer L DarbyDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Upendra K KarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-4065-0860
Matthew D NealDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-8931-6236
Jason SperryDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jishnu DasCenter for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Timothy R BilliarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

TRAINING IN TRAUMA AND SEPSIS RESEARCHT32GM008516 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 1994 to 2026
$9.4M
Vascular Surgery Research Training (VascTrain) ProgramT32HL098036 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Edith Tzeng · 2010 to 2026
$7.2M
Mechanisms of Immune Dysfunction after Trauma and Surgical SepsisR35GM127027 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 2018 to 2026
$5.7M
Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9M
Using three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious diseaseDP2AI164325 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAS, JISHNU · 2021 to 2025
$2.4M
Pittsburgh Innovation in Collaborative Training of Residents AllianceR38HL150207 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Charles S Dela Cruz, Corrine R Kliment · 2020 to 2026
$2.1M
National Institute of Allergy and Infectious Diseases DP2AI164325NHLBI NIH HHS R38 HL150207NHLBI NIH HHS T32 HL098036NIAID NIH HHS DP2 AI164325NIGMS NIH HHS R35 GM119526NIGMS NIH HHS R35 GM127027NIGMS NIH HHS T32 GM008516NIH HHS R35GM119526NIH HHS R35-GM-127027
6 · The paper itself

Abstract

Admission-based circulating biomarkers for the prediction of outcomes in trauma patients could be useful for clinical decision support. It is unknown which molecular classes of biomolecules can contribute biomarkers to predictive modeling. Here, we analyzed a large multi-omic database of over 8500 markers (proteomics, metabolomics, and lipidomics) to identify prognostic biomarkers in the circulating compartment for adverse outcomes, including mortality and slow recovery, in severely injured trauma patients. Admission plasma samples from patients (

Indexed as

biomarkersmachine learningmulti-omicsprognosticproteomicstrauma

Identifiers

PMID36144179
PMCPMC9500723

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.