Evidence map›Paper›PMID 36143962›Full record

ArticleMedicina (Kaunas, Lithuania)2022

Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report.

Arcangelo Iannuzzi, Antonio Parrella, Francesca De Ritis, Anna Cammarota, Lucia Berloco, Francesca Paudice, Giovanni D'Angelo, Emilio Aliberti, Gabriella Iannuzzo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Arcangelo IannuzziDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Antonio ParrellaDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Francesca De RitisDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Anna CammarotaDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Lucia BerlocoDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Francesca PaudiceDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Giovanni D'AngeloDepartment of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Emilio AlibertiDepartment of Acute Internal Medicine, Royal Victoria Infirmary, Newcastle NE1 4LP, UK.
Gabriella IannuzzoDepartment of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
Federico II University Hospital · ITRoyal Victoria Infirmary · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway.

Indexed as

Anemia, AplasticCOVID-19Hemoglobinuria, ParoxysmalPancytopeniaAgedFemaleGlycosylphosphatidylinositolsHumansSARS-CoV-2Glycosylphosphatidylinositolsaplastic anaemiaCOVID-19Paroxysmal Nocturnal HaemoglobinuriaPIGA gene

Identifiers

PMID36143962
PMCPMC9503064
OpenAlexW4296281139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.