ArticleLife (Basel, Switzerland)2022
Neutrophil-to-Lymphocyte Ratio Predicts Early Neurological Deterioration after Endovascular Treatment in Patients with Ischemic Stroke.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07142239 (Comparative Analysis of Hematological Markers MPV, PLR, and NLR in Primary Versus Secondary Antiphospholipid Syndrome), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Analysis of Hematological Markers MPV, PLR, and NLR in Primary Versus Secondary Antiphospholipid Syndrome
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Predictive value of neutrophil to lymphocyte ratio for ischemic stroke in patients with atrial fibrillation: A meta-analysis.Frontiers in neurology · 2022Pooled it
- A new nomogram for predicting the risk of ischemic early neurological deterioration after intravenous thrombolysis in acute ischemic stroke: a multicenter retrospective study.BMC neurology · 2026Article
- Clinical application of the HALP score for predicting early neurological deterioration in older patients with acute cerebral infarction.Biomedical reports · 2026Article
- Integrated predictors of outcome in vertebrobasilar artery occlusion treated With endovascular therapy.Frontiers in surgery · 2026Review
- LncRNA SERPINB9P1 Mitigates Cerebral Injury Induced by Oxygen‒Glucose Deprivation/Reoxygenation by Interacting with HSPA2.Molecular neurobiology · 2025Article
- Article
- Old and New Biomarkers in Idiopathic Recurrent Acute Pericarditis (IRAP): Prognosis and Outcomes.Current cardiology reports · 2025Review
- Correlation between the hemoglobin-to-hematocrit ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study.Frontiers in neurology · 2025Article
- Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Insights into Iron Metabolism Parameters in Ischemic Stroke: A Single-Center Prospective Cohort Study.International journal of molecular sciences · 2024Article
- Relationship of neutrophil/lymphocyte ratio with cerebral small vessel disease and its common imaging markers.Immunity, inflammation and disease · 2024Article
- Association of the Neutrophil-to-Lymphocyte Ratio with 90-Day Functional Outcomes in Patients with Acute Ischemic Stroke.Brain sciences · 2024Article
- Inflammatory markers and functional outcome score in different subgroups of ischaemic stroke: a prospective cohort study.BMJ neurology open · 2024Article
- Body fluids biomarkers associated with prognosis of acute ischemic stroke: progress and prospects.Future science OA · 2024Review
- Postoperative blood glucose increase is associated with futile recanalization in patients with successful thrombectomy: a retrospective study.BMC neurology · 2023Article
- Evaluation of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Systemic Immune-Inflammation Index (SII) as Potential Biomarkers in Patients with Sporadic Medullary Thyroid Cancer (MTC).Journal of personalized medicine · 2023Article
- Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke.Aging · 2023Article
- Neutrophil-to-Lymphocyte Ratio as a Predictor of Short-Term Functional Outcomes in Acute Ischemic Stroke Patients.International journal of environmental research and public health · 2023Article
- Predictive value of neutrophil-to-lymphocyte ratio for atrial fibrillation and stroke in type 2 diabetes mellitus: The Hong Kong Diabetes Study.Endocrinology, diabetes & metabolism · 2023Article
- CNS-LAND score: predicting early neurological deterioration after intravenous thrombolysis based on systemic responses and injury.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The worsening of neurological status that occurs early after acute ischemic stroke (AIS) remains a serious issue, and the inflammatory response plays a key role in stroke pathobiology. Recently, endovascular treatment (EVT) has revolutionized the management and outcome of patients with AIS due to either extracranial carotid disease or intracranial disease. The neutrophil-to-lymphocyte ratio (NLR) represents an easily available inflammatory biomarker. The aim of the study was to assess the relationship between the NLR at admission and the occurrence of early neurological deterioration (END) in patients with AIS who underwent EVT. Patients with AIS and proximal arterial occlusion in the anterior circulation undergoing EVT were retrospectively identified. Absolute neutrophil count (ANC) and absolute lymphocyte count (ALC) were collected from admission blood work to calculate the NLR. The study outcome was END defined as an increase in at least 4 points in NIHSS score or death between baseline and 24 h after the ischemic event. Patients included were 211, and END occurred in 30 (14.2%). Patients with older age (OR = 1.07, 95% CI: 1.02−1.13), higher serum glucose (OR = 1.01, 95% CI: 1.01−1.02), and higher NLR (OR = 1.011, 95% CI: 1.04−1.18) had an increased risk of END. The best predictive cut-off value of NLR was 6.4, and END occurred in 24.1% and 3.9% of the patients with NLR ≥ 6.4 and <6.4, respectively (p < 0.001). In patients with AIS undergoing EVT, higher NLR values predicted a higher risk of END. Biomarkers able to identify inflammatory mechanisms might identify novel treatment targets and enhance proof-of-concept trials of immunomodulation in stroke.
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